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Article: Effects of prenatal cocaine exposure on the developing hippocampus: intrinsic and synaptic physiology.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Baraban SC; Schwartzkroin PA
J. Neurophysiol., 1997


Table 1.

Intrinsic neuronal properties of CA1 pyramidal cells

N RMP, RIN, MΩ τc, ms AP Amp, AP Dur, AHP Amp, AHP Time to Peak, ms SFA τc, DAP, Sag,
mV mV ms mV ms mV mV
P10 neurons * *
Control 10 −59.3 ± 2.4 80.2 ± 15.5 30.3 ± 1.6 60.6 ± 1.7 3.8 ± 0.3 10.1 ± 1.5 175.7 ± 47.9 45.5 ± 8.3 9.5 ± 3.3 6.2 ± 1.3
Cocaine 11 −58.1 ± 3.2 85.3 ± 10.2 38.3 ± 1.4 59.8 ± 2.9 3.5 ± 0.3 8.9 ± 2.7 203 ± 60.1 91.3 ± 20 10.9 ± 2.8 8.4 ± 2.2
P15 neurons * * *
Control 18 −63.6 ± 3.3 80.4 ± 10.4 37 ± 0.6 63.3 ± 0.8 2.3 ± 0.2 6.8 ± 1.2 61.5 ± 19.6 58.4 ± 8.1 13.7 ± 2 4.7 ± 0.6
Cocaine 15 −62.6 ± 3.5 87.1 ± 22.2 37.7 ± 0.6 66.9 ± 3.1 2.6 ± 0.2 7.8 ± 1.2 109.8 ± 21 94.2 ± 12.3 7.6 ± 0.6 9.7 ± 1.6
P20 neurons * *
Control 19 −64.3 ± 2.5 91.6 ± 9.2 37.2 ± 0.9 66.5 ± 1.4 2.4 ± 0.1 7.9 ± 0.7 67.3 ± 14.2 79.4 ± 9.1 10 ± 1.1 5 ± 0.7
Cocaine 17 −63.7 ± 3 81 ± 10.6 36.9 ± 1.1 70.7 ± 2.7 2.3 ± 0.1 4.4 ± 0.6 43.6 ± 4.9 148.9 ± 15.3 9.5 ± 1.1 4.4 ± 0.9

  • Values are means ± SE. RMP, resting membrane potential; R IN, input resistance; τc, membrane time constant; AP Amp, action potential amplitude; AP Dur, action potential duration; AHP, afterhyperpolarization; SFA τc, spike frequency adaptation time constant; DAP, depolarizing afterpotential; sag, anomolous rectification; P, postnatal day.* P < 0.05.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell resting membrane potential -59.3 ± 2.4 (10) -59.3 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 80.2 ± 15.5 (10) 80.2 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (ms) 30.3 ± 1.6 (10) 30.3 (ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude 60.6 ± 1.7 (10) 60.6 (mV) Data Table
Hippocampus CA1 pyramidal cell spike width 3.8 ± 0.3 (10) 3.8 (ms) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude 10.1 ± 1.5 (10) 10.1 (mV) Data Table
Hippocampus CA1 pyramidal cell AHP duration (ms) 175.7 ± 47.9 (10) 175.7 (ms) Data Table
Hippocampus CA1 pyramidal cell ADP amplitude 9.5 ± 3.3 (10) 9.5 (mV) Data Table
Hippocampus CA1 pyramidal cell sag amplitude 6.2 ± 1.3 (10) 6.2 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential -63.6 ± 3.3 (18) -63.6 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 80.4 ± 10.4 (18) 80.4 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (ms) 37.0 ± 0.6 (18) 37.0 (ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude 63.3 ± 0.8 (18) 63.3 (mV) Data Table
Hippocampus CA1 pyramidal cell spike width 2.3 ± 0.2 (18) 2.3 (ms) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude 6.8 ± 1.2 (18) 6.8 (mV) Data Table
Hippocampus CA1 pyramidal cell AHP duration (ms) 61.5 ± 19.6 (18) 61.5 (ms) Data Table
Hippocampus CA1 pyramidal cell ADP amplitude 13.7 ± 2.0 (18) 13.7 (mV) Data Table
Hippocampus CA1 pyramidal cell sag amplitude 4.7 ± 0.6 (18) 4.7 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential -64.3 ± 2.5 (19) -64.3 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 91.6 ± 9.2 (19) 91.6 (MΩ) Data Table
Hippocampus CA1 pyramidal cell membrane time constant (ms) 37.2 ± 0.9 (19) 37.2 (ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude 66.5 ± 1.4 (19) 66.5 (mV) Data Table
Hippocampus CA1 pyramidal cell spike width 2.4 ± 0.1 (19) 2.4 (ms) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude 7.9 ± 0.7 (19) 7.9 (mV) Data Table
Hippocampus CA1 pyramidal cell AHP duration (ms) 67.3 ± 14.2 (19) 67.3 (ms) Data Table
Hippocampus CA1 pyramidal cell ADP amplitude 10.0 ± 1.1 (19) 10.0 (mV) Data Table
Hippocampus CA1 pyramidal cell sag amplitude 5.0 ± 0.7 (19) 5.0 (mV) Data Table