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Article: Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome.

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Kaphzan H; Buffington SA; Jung JI; Rasband MN; Klann E
J. Neurosci., 2011

Table 1.

Passive intrinsic properties of CA1 pyramidal cells

Parameter WT AS p value
Resting potential (mV) −61.7 (±1.5) −66.4 (±1.5) <0.05
Time constant 29.2 (1.9) 29.0 (2.0) ns
Input resistance (MΩ) 237.8 (13.2) 239.8 (13.1) ns
  • Altered passive intrinsic properties in hippocampal CA1 pyramidal neurons from AS model mice and their wild-type littermates. Resting potential is significantly more hyperpolarized in AS mice (WT: n = 15 cells, 5 mice; AS: n = 15 cells, 5 mice).

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell input resistance 237.8 237.8 (MΩ) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -61.7 ± 1.5 -61.7 (mV) Data Table
Hippocampus CA1 pyramidal cell membrane time constant 29.2 29.2 (ms) Data Table