Article: Changes in membrane excitability and potassium currents in sensitized dorsal horn neurons of mice pups.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Rivera-Arconada I; Lopez-Garcia JA J. Neurosci., 2010
Control | Carrageenan-treated 20 h | NMDA-treated | Carrageenan-treated 1 h | |
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Basic electrophysiological properties | ||||
n | 21 | 8 | 14 | 11 |
RMP (mV) | −55.7 ± 1.5 | −54.2 ± 2.2 | −54.3 ± 1.3 | −55.4 ± 2.2 |
Rin (MΩ) | 445 ± 42 | 486 ± 38 | 360 ± 34 | 439 ± 61 |
Capacitance (pF) | 19.5 ± 1.8 | 16.5 ± 2.0 | 17.4 ± 2.5 | 15.6 ± 2.6 |
Sustained currents | ||||
n | 21 | 8 | 14 | 11 |
Max. current density (pA/pF) | 25.7 ± 4.1 | 48.2 ± 8.8* | 78.0 ± 13.9** | 55.2 ± 18.6 |
Max. voltage attained (mV) | 21 | 19 | 21 | 23 |
Slope activation | 0.6 ± 0.1 | 1.2 ± 0.2* | 1.7 ± 0.3** | 1.1 ± 0.4 |
V50 (mV) | 2.1 ± 1.1 | 2.6 ± 1.4 | 0.4 ± 1.6 | −9.2 ± 1.2*** |
K | 15.1 ± 0.5 | 10.7 ± 0.6*** | 13.5 ± 0.6 | 12.1 ± 0.4*** |
Transient currents | ||||
n | 18 | 8 | 11 | 7 |
Max. current density (pA/pF) | 15.3 ± 3.3 | 18.4 ± 2.9 | 39.0 ± 13.1* | 18.7 ± 9.3 |
Max. voltage attained (mV) | 8 | 10 | 10 | 8 |
V50 (mV) | −10.7 ± 2.9 | −15.6 ± 2.7 | −14.4 ± 1.1 | −8.1 ± 7.3 |
K | 11.9 ± 1.8 | 10.8 ± 2.0 | 8.3 ± 1.2* | 12.0 ± 1.7 |
Time constant (ms) | 15.9 ± 1.5 | 15.7 ± 2.1 | 15.5 ± 2.5 | 27.2 ± 9.3 |
Activation | ||||
V50 (mV) | −22.1 ± 1.8 | −24.2 ± 2.7 | −20.4 ± 1.2 | −22.0 ± 3.6 |
K | 9.3 ± 0.9 | 8.7 ± 1.5 | 7.1 ± 1.1 | 8.5 ± 0.7 |
Inactivation | ||||
V50 (mV) | −43.9 ± 1.7 | −39.4 ± 2.8 | −47.0 ± 2.0 | −54.3 ± 4.9 |
K | −10.5 ± 1.0 | −12.6 ± 1.6 | −9.7 ± 1.2 | −15.5 ± 1.9* |
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↵Values are means ± SEM. Values for maximum (Max.) current density were obtained at the maximum voltage attained as indicated. Density of sustained currents for voltages over −18 mV were fitted to a straight line and slope values are given. For data fitted to the Boltzmann sigmoidal function, V50, voltage of half-maximal activation or inactivation, and K, slope factor. The inactivation time constant was obtained fitting isolated transient currents obtained at ≈+10 mV to a single exponential function. Asterisks stand for statistical significance using Mann–Whitney test. Levels of confidence are as follows: *p < 0.05,
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↵**p < 0.01,
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↵*** p < 0.001. n, Number of neurons; RMP, resting membrane potential; Rin, input resistance.
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Dorsal root ganglion cell | resting membrane potential (mV) | -55.7 ± 1.5 | -55.7 (mV) | Data Table | |
Dorsal root ganglion cell | input resistance (MΩ) | 445.0 ± 42.0 | 445.0 (MΩ) | Data Table | |
Dorsal root ganglion cell | cell capacitance (pF) | 19.5 ± 1.8 | 19.5 (pF) | Data Table | |
Dorsal root ganglion cell | membrane time constant (ms) | 15.9 ± 1.5 | 15.9 (ms) | Data Table |