Article: Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Paz JT; Christian CA; Parada I; Prince DA; Huguenard JR J. Neurosci., 2010
Vm (mV) | AP ampl. (mV) | AP duration (ms) | AP threshold (mV) | AHP ampl. (mV) | F–I slope (Hz/pA) | Rheobase (pA) | |
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Control | −69.2 ± 5.2 | 60.9 ± 2.5 | 1.6 ± 0.1 | −57.8 ± 1.2 | 16.8 ± 0.95 | 0.31 ± 0.04 | 34.3 ± 2.5 |
Injured | −66.5 ± 6.2 | 65.5 ± 2.2 | 1.5 ± 0.2 | −55.4 ± 0.9 | 18.9 ± 1.04 | 0.21 ± 0.01 | 63.3 ± 10.1 |
ANOVA | ns | ns | ns | ns | ns | p < 0.05 | p < 0.001 |
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The membrane resting potential (V m) and AP properties were calculated from 26 injured and 33 control nRT cells and were similar in both groups. F–I curve slope and rheobase were calculated from 24 injured and 30 control cells and were both significantly altered in the injured nRT cells compared with the control cells. All values are expressed as means ± SEM. AHP, Afterhyperpolarization; ampl., amplitude.
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ns, Not significant (p > 0.05).