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Article: Differential responses to NMDA receptor activation in rat hippocampal interneurons and pyramidal cells may underlie enhanced pyramidal cell vulnerability.

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Avignone E; Frenguelli BG; Irving AJ
Eur. J. Neurosci., 2005


Table 1.  Pyramidal cells and interneurons display different electrophysiological properties
Parameters (and units)Pyramidal cells (n = 52) Interneurons (n = 30)
Mean ± SEMCVMean ± SEMCV

  1. Data are expressed as mean ± SEM and were obtained from 52 pyramidal cells and 30 interneurons. Note that interneurons had higher coefficients of variance (CV) for almost all parameters than did pyramidal cells. **P < 0.01. Vm, resting membrane potential; AHP, afterhyperpolarization; Rin, input resistance; Cm, membrane capacitance.

Vm (mV)−66.4 ± 0.4−0.048−58.4 ± 1.3**−0.13
Spike
 Threshold (mV)−52.3 ± 0.7−0.096−48.0 ± 1.5**−0.17
 Amplitude (mV)107.4 ± 0.90.0689.0 ± 1.9**0.11
AHP (mV)5.2 ± 0.40.6220.5 ± 0.9**0.23
Max. freq. (Hz)18.9 ± 0.70.2638.6 ± 3.1**0.44
Rin (MΩ)336 ± 120.26573 ± 54**0.50
Cm (pF )75.9 ± 1.60.1549.6 ± 3.4**0.36

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 IS-I neuron Hippocampus stratum oriens alveus interneurons spike threshold (mV) -48.0 ± 1.5 (30) -48.0 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 107.4 ± 0.9 (52) 107.4 (mV) Data Table
Hippocampus CA1 IS-I neuron Hippocampus stratum oriens alveus interneurons spike amplitude (mV) 89.0 ± 1.9 (30) 89.0 (mV) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude (mV) 5.2 ± 0.4 (52) 5.2 (mV) Data Table
Hippocampus CA1 IS-I neuron Hippocampus stratum oriens alveus interneurons AHP amplitude (mV) 20.5 ± 0.9 (30) 20.5 (mV) Data Table
Hippocampus CA1 pyramidal cell maximum firing rate (Hz) 18.9 ± 0.7 (52) 18.9 (Hz) Data Table
Hippocampus CA1 IS-I neuron Hippocampus stratum oriens alveus interneurons maximum firing rate (Hz) 38.6 ± 3.1 (30) 38.6 (Hz) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 336.0 ± 12.0 (52) 336.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -66.4 ± 0.4 (52) -66.4 (mV) Data Table
Hippocampus CA1 IS-I neuron Hippocampus stratum oriens alveus interneurons input resistance (MΩ) 573.0 ± 54.0 (30) 573.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell cell capacitance (pF ) 75.9 ± 1.6 (52) 75.9 (pF) Data Table
Hippocampus CA1 IS-I neuron Hippocampus stratum oriens alveus interneurons cell capacitance (pF ) 49.6 ± 3.4 (30) 49.6 (pF) Data Table
Hippocampus CA1 IS-I neuron Hippocampus stratum oriens alveus interneurons resting membrane potential (mV) -58.4 ± 1.3 (30) -58.4 (mV) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -52.3 ± 0.7 (52) -52.3 (mV) Data Table