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Article: A functional null mutation of SCN1B in a patient with Dravet syndrome.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Patino GA; Claes LR; Lopez-Santiago LF; Slat EA; Dondeti RS; Chen C; O'Malley HA; Gray CB; Miyazaki H; Nukina N; Oyama F; De Jonghe P; Isom LL
J. Neurosci., 2009


Table 5.

Analysis of evoked action potentials in CA1 or CA3 hippocampal slices from Scn1b+/+ and Scn1b−/− mice

Scn1b+/+ Scn1b−/−
CA1
    Resting potential (mV) −71.99 ± 1.21 −71.78 ± 0.76
    Input resistance (MΩ) 142.60 ± 27.68 141.36 ± 11.23
    Threshold (mV) −33.81 ± 2.00 −33.00 ± 1.50
    Rise time (ms) 0.76 ± 0.03 0.67 ± 0.03
    Peak voltage (mV) 35.48 ± 1.91 33.73 ± 2.16
    Amplitude (mV) 69.29 ± 2.90 66.74 ± 2.36
    n 22 19
CA3
    Resting potential (mV) −72.96 ± 0.54 −71.74 ± 0.59
    Input resistance (MΩ) 156.99 ± 5.97 161.75 ± 11.06
    Threshold (mV) −33.82 ± 0.75 −35.73 ± 0.78
    Rise time (ms) 0.61 ± 0.02 0.52 ± 0.01
    Peak voltage (mV) 38.77 ± 1.49 46.36 ± 1.21*
    Amplitude (mV) 72.59 ± 1.60 82.10 ± 1.29
    n 34 21
  • Data are mean ± SEM.

  • *p = 0.001 compared with Scn1b+/+.

  • p < 0.001 compared with Scn1b+/+.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -71.99 ± 1.21 (34) -71.99 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 142.6 ± 27.68 (34) 142.6 (MΩ) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -33.81 ± 2.0 (34) -33.81 (mV) Data Table
Hippocampus CA1 pyramidal cell spike rise time (ms) 0.76 ± 0.03 (34) 0.76 (ms) Data Table
Hippocampus CA1 pyramidal cell spike peak (mV) 35.48 ± 1.91 (34) 35.48 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 69.29 ± 2.9 (34) 69.29 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -72.96 ± 0.54 (34) -72.96 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 156.99 ± 5.97 (34) 156.99 (MΩ) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -33.82 ± 0.75 (34) -33.82 (mV) Data Table
Hippocampus CA1 pyramidal cell spike rise time (ms) 0.61 ± 0.02 (34) 0.61 (ms) Data Table
Hippocampus CA1 pyramidal cell spike peak (mV) 38.77 ± 1.49 (34) 38.77 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 72.59 ± 1.6 (34) 72.59 (mV) Data Table