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Article: Failure to mount adaptive responses to stress results in dysregulation and cell death in the midbrain raphe.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
McEuen JG; Beck SG; Bale TL
J. Neurosci., 2008


Table 2.

Active and passive cell characteristics in whole-cell recordings of cells in vmDR

Cell type (n) Vm rest (mV)* R (mW) Tau (ms) AHP Amp (mV) AP threshold (mV) AP Amp (mV) Peak AP height AP duration (ms)**
WT 5-HT− (19) −60.9 ± 1.6 464.0 ± 22.4 37.8 ± 4.3 24.0 ± 2.0 −24.2 ± 3.3 48.5 ± 2.3 21.0 ± 2.2 1.5 ± 0.07
WT 5-HT+ (8) −61.3 ± 2.8 447.1 ± 53.9 39.1 ± 4.3 26.2 ± 0.7 −28.0 ± 2.6 50.0 ± 4.4 22.0 ± 3.3 1.8 ± 0.07
KO 5-HT− (14) −54.9 ± 1.5 475.0 ± 25.7 42.7 ± 2.5 26.1 ± 1.0 −28.4 ± 1.0 52.4 ± 2.7 24.0 ± 1.8 1.6 ± 0.07
KO 5-HT+ (11) −57.9 ± 2.3 415.5 ± 36.6 42.7 ± 6.3 24.9 ± 0.8 −28.0 ± 1.2 50.0 ± 3.3 20.1 ± 3.0 2.1 ± 0.36

  • Recordings were taken from 5-HT+ and non-5-HT (5-HT−) cells in WT and stress-sensitive (KO) mice. Vm, Resting membrane potential; R, resistance; AHP, afterhyperpolarization; Amp, amplitude; AP, action potential. Values are expressed as mean ± SEM.

  • ↵*p ≤ 0.05, significant difference across genotypes.

  • ↵**p ≤ 0.05, significant difference across 5-HT+ and 5-HT− cells.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Ventromedial dorsal raphe non-serotonergic neuron resting membrane potential (mV) -60.9 ± 1.6 (19) -60.9 (mV) Data Table
Other Ventromedial dorsal raphe non-serotonergic neuron input resistance (mW) 464.0 ± 22.4 (19) 464.0 (MΩ) Data Table
Other Ventromedial dorsal raphe non-serotonergic neuron membrane time constant (ms) 37.8 ± 4.3 (19) 37.8 (ms) Data Table
Other Ventromedial dorsal raphe non-serotonergic neuron AHP amplitude (mV) 24.0 ± 2.0 (19) 24.0 (mV) Data Table
Other Ventromedial dorsal raphe non-serotonergic neuron spike threshold (mV) -24.2 ± 3.3 (19) -24.2 (mV) Data Table
Other Ventromedial dorsal raphe non-serotonergic neuron spike amplitude (mV) 48.5 ± 2.3 (19) 48.5 (mV) Data Table
Other Ventromedial dorsal raphe non-serotonergic neuron spike peak 21.0 ± 2.2 (19) 21.0 (mV) Data Table
Other Ventromedial dorsal raphe non-serotonergic neuron spike width (ms) 1.5 ± 0.07 (19) 1.5 (ms) Data Table
Other Ventromedial dorsal raphe serotonergic neuron resting membrane potential (mV) -61.3 ± 2.8 (8) -61.3 (mV) Data Table
Other Ventromedial dorsal raphe serotonergic neuron input resistance (mW) 447.1 ± 53.9 (8) -- Data Table
Other Ventromedial dorsal raphe serotonergic neuron membrane time constant (ms) 39.1 ± 4.3 (8) 39.1 (ms) Data Table
Other Ventromedial dorsal raphe serotonergic neuron AHP amplitude (mV) 26.2 ± 0.7 (8) 26.2 (mV) Data Table
Other Ventromedial dorsal raphe serotonergic neuron spike threshold (mV) -28.0 ± 2.6 (8) -28.0 (mV) Data Table
Other Ventromedial dorsal raphe serotonergic neuron spike amplitude (mV) 50.0 ± 4.4 (8) 50.0 (mV) Data Table
Other Ventromedial dorsal raphe serotonergic neuron spike peak 22.0 ± 3.3 (8) 22.0 (mV) Data Table
Other Ventromedial dorsal raphe serotonergic neuron spike width (ms) 1.8 ± 0.07 (8) 1.8 (ms) Data Table