Article: Failure to mount adaptive responses to stress results in dysregulation and cell death in the midbrain raphe.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) McEuen JG; Beck SG; Bale TL J. Neurosci., 2008
Cell type (n) | Vm rest (mV)* | R (mW) | Tau (ms) | AHP Amp (mV) | AP threshold (mV) | AP Amp (mV) | Peak AP height | AP duration (ms)** |
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WT 5-HT− (19) | −60.9 ± 1.6 | 464.0 ± 22.4 | 37.8 ± 4.3 | 24.0 ± 2.0 | −24.2 ± 3.3 | 48.5 ± 2.3 | 21.0 ± 2.2 | 1.5 ± 0.07 |
WT 5-HT+ (8) | −61.3 ± 2.8 | 447.1 ± 53.9 | 39.1 ± 4.3 | 26.2 ± 0.7 | −28.0 ± 2.6 | 50.0 ± 4.4 | 22.0 ± 3.3 | 1.8 ± 0.07 |
KO 5-HT− (14) | −54.9 ± 1.5 | 475.0 ± 25.7 | 42.7 ± 2.5 | 26.1 ± 1.0 | −28.4 ± 1.0 | 52.4 ± 2.7 | 24.0 ± 1.8 | 1.6 ± 0.07 |
KO 5-HT+ (11) | −57.9 ± 2.3 | 415.5 ± 36.6 | 42.7 ± 6.3 | 24.9 ± 0.8 | −28.0 ± 1.2 | 50.0 ± 3.3 | 20.1 ± 3.0 | 2.1 ± 0.36 |
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Recordings were taken from 5-HT+ and non-5-HT (5-HT−) cells in WT and stress-sensitive (KO) mice. Vm, Resting membrane potential; R, resistance; AHP, afterhyperpolarization; Amp, amplitude; AP, action potential. Values are expressed as mean ± SEM.
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↵*p ≤ 0.05, significant difference across genotypes.
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↵**p ≤ 0.05, significant difference across 5-HT+ and 5-HT− cells.