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Article: Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Lin YW; Min MY; Lin CC; Chen WN; Wu WL; Yu HM; Chen CC
Neuroscience, 2008


Table 2Electrophysiological properties of four acid-sensitivity groups of lumbar DRG neurons
SAS (n=55)SART (n=20)SARS (n=110)NAC (n=90)
Diameter (μm)38.1±0.735.9±1.434.4±0.7⁎⁎33.1±0.8⁎⁎
Capacitance (pF)31.5±1.825.3±2.826.2±1.2⁎26.8±1.5
Vm (mV)−55.5±1.0−53.1±1.8−50.9±0.9⁎⁎−47.5±0.9⁎⁎
AP (ms)6.4±0.38.8±2.57.9±0.7⁎7.8±0.5⁎
Half AP (ms)3.1±0.22.7±0.23.3±0.23.7±0.2
AP rise time (ms)2.2±0.12.2±0.22.1±0.12.4±0.1
AP fall time (ms)4.2±0.36.7±2.65.8±0.7⁎5.4±0.5⁎
Overshoot (mV)47.9±3.753.6±4.439.9±2.0⁎35.1±2.2⁎⁎
AP threshold (pA)578.8±46.9455.8±75.3395.2±38.3⁎424.0±38.8⁎
AHP (ms)187.1±17.5161.4±24.3117.7±10.1⁎⁎102.2±9.4⁎⁎
Multiple spike (%)9.11527.316.7
TTXr (%)30.94046.445.6
Inflection (%)34.62035.533.3
Capsaicin (%)38.21029.10
IB4 (%)5.5533.628.9
ASIC rising time (ms)62.4±6.368.7±4.6NANA
Desensitization time (s)0.5±0.11.5±0.6⁎⁎NANA
Inhibition by SA (%)39.8±3.3NANANA
Peak amplitude (pA)912.8±117.3294.1±30⁎⁎112.3±15.9⁎⁎NA
Current density (pQ)867.7±98.9636.8±83.3345.3±43.5⁎⁎NA
Four acid-sensitivity groups exhibited distinct electrophysiological properties. Vm, resting membrane potential; ASIC, acid-sensing ion channel. Only among SAS neurons was the acid-evoked current sensitive to SA inhibition. The SAS neurons showed unique electrophysiological properties as compared with other groups. NA: nonapplicable.⁎P<0.05 compared with SAS values.⁎⁎P<0.01 compared with SAS values.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell lumbar dorsal root ganglion neuron cell capacitance (pF) 31.5 ± 1.8 31.5 (pF) Data Table
Dorsal root ganglion cell lumbar dorsal root ganglion neuron resting membrane potential (mV) -55.5 ± 1.0 -55.5 (mV) Data Table
Dorsal root ganglion cell lumbar dorsal root ganglion neuron spike width (ms) 6.4 ± 0.3 6.4 (ms) Data Table
Dorsal root ganglion cell lumbar dorsal root ganglion neuron spike half-width (ms) 3.1 ± 0.2 3.1 (ms) Data Table
Dorsal root ganglion cell lumbar dorsal root ganglion neuron spike peak (mV) 47.9 ± 3.7 47.9 (mV) Data Table
Dorsal root ganglion cell lumbar dorsal root ganglion neuron rheobase (pA) 578.8 ± 46.9 578.8 (pA) Data Table
Dorsal root ganglion cell lumbar dorsal root ganglion neuron AHP duration (ms) 187.1 ± 17.5 187.1 (ms) Data Table
Dorsal root ganglion cell lumbar dorsal root ganglion neuron cell diameter (μm) 38.1 ± 0.7 38.1 (um) Data Table