Article: Identification and characterization of a subset of mouse sensory neurons that express acid-sensing ion channel 3.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Lin YW; Min MY; Lin CC; Chen WN; Wu WL; Yu HM; Chen CC Neuroscience, 2008
Table 2Electrophysiological properties of four acid-sensitivity groups of lumbar DRG neurons
Four acid-sensitivity groups exhibited distinct electrophysiological properties. Vm, resting membrane potential; ASIC, acid-sensing ion channel. Only among SAS neurons was the acid-evoked current sensitive to SA inhibition. The SAS neurons showed unique electrophysiological properties as compared with other groups. NA: nonapplicable.⁎P<0.05 compared with SAS values.⁎⁎P<0.01 compared with SAS values.
SAS (n=55) | SART (n=20) | SARS (n=110) | NAC (n=90) | |
Diameter (μm) | 38.1±0.7 | 35.9±1.4 | 34.4±0.7⁎⁎ | 33.1±0.8⁎⁎ |
Capacitance (pF) | 31.5±1.8 | 25.3±2.8 | 26.2±1.2⁎ | 26.8±1.5 |
Vm (mV) | −55.5±1.0 | −53.1±1.8 | −50.9±0.9⁎⁎ | −47.5±0.9⁎⁎ |
AP (ms) | 6.4±0.3 | 8.8±2.5 | 7.9±0.7⁎ | 7.8±0.5⁎ |
Half AP (ms) | 3.1±0.2 | 2.7±0.2 | 3.3±0.2 | 3.7±0.2 |
AP rise time (ms) | 2.2±0.1 | 2.2±0.2 | 2.1±0.1 | 2.4±0.1 |
AP fall time (ms) | 4.2±0.3 | 6.7±2.6 | 5.8±0.7⁎ | 5.4±0.5⁎ |
Overshoot (mV) | 47.9±3.7 | 53.6±4.4 | 39.9±2.0⁎ | 35.1±2.2⁎⁎ |
AP threshold (pA) | 578.8±46.9 | 455.8±75.3 | 395.2±38.3⁎ | 424.0±38.8⁎ |
AHP (ms) | 187.1±17.5 | 161.4±24.3 | 117.7±10.1⁎⁎ | 102.2±9.4⁎⁎ |
Multiple spike (%) | 9.1 | 15 | 27.3 | 16.7 |
TTXr (%) | 30.9 | 40 | 46.4 | 45.6 |
Inflection (%) | 34.6 | 20 | 35.5 | 33.3 |
Capsaicin (%) | 38.2 | 10 | 29.1 | 0 |
IB4 (%) | 5.5 | 5 | 33.6 | 28.9 |
ASIC rising time (ms) | 62.4±6.3 | 68.7±4.6 | NA | NA |
Desensitization time (s) | 0.5±0.1 | 1.5±0.6⁎⁎ | NA | NA |
Inhibition by SA (%) | 39.8±3.3 | NA | NA | NA |
Peak amplitude (pA) | 912.8±117.3 | 294.1±30⁎⁎ | 112.3±15.9⁎⁎ | NA |
Current density (pQ) | 867.7±98.9 | 636.8±83.3 | 345.3±43.5⁎⁎ | NA |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Dorsal root ganglion cell | lumbar dorsal root ganglion neuron | cell capacitance (pF) | 31.5 ± 1.8 | 31.5 (pF) | Data Table |
Dorsal root ganglion cell | lumbar dorsal root ganglion neuron | resting membrane potential (mV) | -55.5 ± 1.0 | -55.5 (mV) | Data Table |
Dorsal root ganglion cell | lumbar dorsal root ganglion neuron | spike width (ms) | 6.4 ± 0.3 | 6.4 (ms) | Data Table |
Dorsal root ganglion cell | lumbar dorsal root ganglion neuron | spike half-width (ms) | 3.1 ± 0.2 | 3.1 (ms) | Data Table |
Dorsal root ganglion cell | lumbar dorsal root ganglion neuron | spike peak (mV) | 47.9 ± 3.7 | 47.9 (mV) | Data Table |
Dorsal root ganglion cell | lumbar dorsal root ganglion neuron | rheobase (pA) | 578.8 ± 46.9 | 578.8 (pA) | Data Table |
Dorsal root ganglion cell | lumbar dorsal root ganglion neuron | AHP duration (ms) | 187.1 ± 17.5 | 187.1 (ms) | Data Table |
Dorsal root ganglion cell | lumbar dorsal root ganglion neuron | cell diameter (μm) | 38.1 ± 0.7 | 38.1 (um) | Data Table |