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Article: Transgenic mouse lines subdivide medial vestibular nucleus neurons into discrete, neurochemically distinct populations.

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Bagnall MW; Stevens RJ; du Lac S
J. Neurosci., 2007


Table 2.

Intrinsic characteristics of YFP-16 and GIN neurons in the MVN are distinct at both physiological and room temperatures

Physiological temperature (34°C) n p value Room temperature (23° C)
YFP-16 GIN YFP-16 GIN YFP-16 GIN
AP width (ms) 0.52 ± 0.11 0.82 ± 0.20 49 59 <0.0001 0.68 ± 0.10 0.96 ± 0.18
AP half-width (ms) 0.19 ± 0.05 0.36 ± 0.10 49 59 <0.0001 0.28 ± 0.05 0.42 ± 0.09
AHP (mV) 19.6 ± 3.4 26.2 ± 4.7 49 59 <0.0001 19.2 ± 3.0 23.3 ± 3.0
Maximum derivation (V/s) 521 ± 102 345 ± 84 49 59 <0.0001 450 ± 101 328 ± 76
Minimum derivation (V/s) 444 ± 117 224 ± 69 49 59 <0.0001 340 ± 92 202 ± 47
ADP (V/s) 5.14 ± 4.28 −2.48 ± 1.56 49 59 <0.0001 5.85 ± 2.99 −0.96 ± 1.22
Threshold (mV) −50.7 ± 4.0 −45.3 ± 4.4 49 50 <0.0001 −48.6 ± 5.5 −47.1 ± 3.6
Input resistance (MΩ) 107 ± 92 269 ± 137 44 51 <0.0001 114 ± 76a 400 ± 180a
Maximum firing rate (Hz) 353 ± 121 154 ± 44 40 43 <0.0001 307 ± 84 118 ± 26
Adaptation ratio (40 Hz) 0.81 ± 0.13 0.91 ± 0.09 48 44 <0.0001 0.82 ± 0.10 0.93 ± 0.08
Gain <80 Hz (Hz/nA) 242 ± 117 242 ± 122 48 49 0.996 217 ± 81 268 ± 134
Gain >80 Hz (Hz/nA) 158 ± 84 206 ± 93 46 46 0.011 134 ± 75 203 ± 103
Gain/input resistance 1.90 ± 0.85 0.81 ± 0.38 42 41 <0.0001 1.32 ± 0.56 0.59 ± 0.36
Rebound firing (Hz) 42 ± 40 12 ± 13 38 24 <0.0001 53 ± 61 n/a
  • Room temperature recordings were as follows: for spike parameters, n = 26 (YFP-16) and 37 (GIN); for cell parameters, n = 14–37. With the exception of threshold and gain <80 Hz, all parameters are significantly different between YFP-16 and GIN at 23°C (p < 0.05). Values indicate mean ± SD.

  • aSome input resistance measurements were made in voltage clamp rather than current clamp.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike half-width (ms) 0.28 ± 0.05 (26) 0.28 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike half-width (ms) 0.42 ± 0.09 (37) 0.42 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron AHP amplitude (mV) 19.6 ± 3.4 (49) 19.6 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron AHP amplitude (mV) 26.2 ± 4.7 (59) 26.2 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron AHP amplitude (mV) 19.2 ± 3.0 (26) 19.2 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron AHP amplitude (mV) 23.3 ± 3.0 (37) 23.3 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike max rise slope (V/s) 521.0 ± 102.0 (49) 521.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike max rise slope (V/s) 345.0 ± 84.0 (59) 345.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike max rise slope (V/s) 450.0 ± 101.0 (26) 450.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike max rise slope (V/s) 328.0 ± 76.0 (37) 328.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike max decay slope (V/s) 444.0 ± 117.0 (49) 444.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike max decay slope (V/s) 224.0 ± 69.0 (59) 224.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike max decay slope (V/s) 340.0 ± 92.0 (26) 340.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike max decay slope (V/s) 202.0 ± 47.0 (37) 202.0 (mV/ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike threshold (mV) -50.7 ± 4.0 (49) -50.7 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike threshold (mV) -45.3 ± 4.4 (59) -45.3 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike threshold (mV) -48.6 ± 5.5 (26) -48.6 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike threshold (mV) -47.1 ± 3.6 (37) -47.1 (mV) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron input resistance (MΩ) 107.0 ± 92.0 (49) 107.0 (MΩ) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron input resistance (MΩ) 269.0 ± 137.0 (59) 269.0 (MΩ) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron input resistance (MΩ) 114.0 ± 76.0 (26) 114.0 (MΩ) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron input resistance (MΩ) 400.0 ± 180.0 (37) 400.0 (MΩ) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron maximum firing rate (Hz) 353.0 ± 121.0 (49) 353.0 (Hz) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron maximum firing rate (Hz) 154.0 ± 44.0 (59) 154.0 (Hz) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron maximum firing rate (Hz) 307.0 ± 84.0 (26) 307.0 (Hz) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron maximum firing rate (Hz) 118.0 ± 26.0 (37) 118.0 (Hz) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron adaptation ratio (40 Hz) 0.81 ± 0.13 (49) 0.81 (ratio) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron adaptation ratio (40 Hz) 0.91 ± 0.09 (59) 0.91 (ratio) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron adaptation ratio (40 Hz) 0.82 ± 0.1 (26) 0.82 (ratio) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron adaptation ratio (40 Hz) 0.93 ± 0.08 (37) 0.93 (ratio) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron FI slope (Hz/nA) 158.0 ± 84.0 (49) 158.0 (Hz/nA) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron FI slope (Hz/nA) 206.0 ± 93.0 (59) 206.0 (Hz/nA) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron FI slope (Hz/nA) 134.0 ± 75.0 (26) 134.0 (Hz/nA) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron FI slope (Hz/nA) 203.0 ± 103.0 (37) 203.0 (Hz/nA) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike width (ms) 0.52 ± 0.11 (49) 0.52 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike width (ms) 0.82 ± 0.2 (59) 0.82 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike width (ms) 0.68 ± 0.1 (26) 0.68 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike width (ms) 0.96 ± 0.18 (37) 0.96 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus glutamatergic or glycinergic neuron spike half-width (ms) 0.19 ± 0.05 (49) 0.19 (ms) Data Table
Medial vestibular nucleus neuron medial vestibular nucleus gabaergic neuron spike half-width (ms) 0.36 ± 0.1 (59) 0.36 (ms) Data Table