Article: Two electrophysiologically distinct types of granule cells in epileptic human hippocampus.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Dietrich D; Clusmann H; Kral T; Steinhäuser C; Blümcke I; Heinemann U; Schramm J Neuroscience, 1999
Table 1Intrinsic properties of granule cells from epileptic human hippocampus
*Data are given as mean±M.D. *Statistically significant difference between type I and type II cells (α=0.05).††Only 21 neurons were averaged; see ‡.*‡Only 16 neurons were averaged. Three type I cells were excluded from this analysis because the number of APs evoked by the current pulse protocol fell out of range.*§0.47±0.15nA were injected, which depolarized the cells to −50±4mV.∥∥0.46±0.17nA were injected, which depolarized the cells to −46±3mV.
Pooled (n=24) | Type I (n=19) | Type II (n=5) | |
Resting potential (mV) | −70±6 | −71±6 | −66±7 |
Input resistance (MΩ) | 58±13 | 59±13 | 54±12 |
Time constant (ms) | 12.1±2.8 | 11.9±3.0 | 13.0±1.9 |
Threshold (mV) | −53±5 | −54±5 | −50±3 |
AP amplitude (mV) | 64±8 | 61±6 | 75±5* |
AP duration (ms) | 1.3±0.2 | 1.3±0.2 | 1.3±0.1 |
AP rise (V/s) | 272±55 | 249±43 | 358±28* |
AP decay (V/s) | −124±21 | −120±22 | −140±16 |
dV/dt ratio | 2.2±0.3 | 2.1±0.3 | 2.6±0.3* |
Fast AHP amplitude (mV) | 10.4±3.1 | 11.2±2.6 | 7.2±3.3* |
AHP 1/4 decay time (ms) | 35±17 | 28±13 | 61±5* |
Spike frequency adaptation | 3.1±1.1† | 2.6±0.8‡§ | 4.8±1.0*∥ |