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Article: Two electrophysiologically distinct types of granule cells in epileptic human hippocampus.

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Dietrich D; Clusmann H; Kral T; Steinhäuser C; Blümcke I; Heinemann U; Schramm J
Neuroscience, 1999


Table 1Intrinsic properties of granule cells from epileptic human hippocampus
Pooled (n=24)Type I (n=19)Type II (n=5)
Resting potential (mV)−70±6−71±6−66±7
Input resistance (MΩ)58±1359±1354±12
Time constant (ms)12.1±2.811.9±3.013.0±1.9
Threshold (mV)−53±5−54±5−50±3
AP amplitude (mV)64±861±675±5*
AP duration (ms)1.3±0.21.3±0.21.3±0.1
AP rise (V/s)272±55249±43358±28*
AP decay (V/s)−124±21−120±22−140±16
dV/dt ratio2.2±0.32.1±0.32.6±0.3*
Fast AHP amplitude (mV)10.4±3.111.2±2.67.2±3.3*
AHP 1/4 decay time (ms)35±1728±1361±5*
Spike frequency adaptation3.1±1.1†2.6±0.8‡§4.8±1.0*∥
*Data are given as mean±M.D. *Statistically significant difference between type I and type II cells (α=0.05).††Only 21 neurons were averaged; see ‡.*‡Only 16 neurons were averaged. Three type I cells were excluded from this analysis because the number of APs evoked by the current pulse protocol fell out of range.*§0.47±0.15nA were injected, which depolarized the cells to −50±4mV.∥∥0.46±0.17nA were injected, which depolarized the cells to −46±3mV.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other CA3 projecting hippocampus Granule Cell input resistance (MΩ) 58.0 ± 13.0 58.0 (MΩ) Data Table
Other CA3 projecting hippocampus Granule Cell membrane time constant (ms) 12.1 ± 2.8 12.1 (ms) Data Table
Other CA3 projecting hippocampus Granule Cell spike threshold (mV) -53.0 ± 5.0 -53.0 (mV) Data Table
Other CA3 projecting hippocampus Granule Cell other (mV) 64.0 ± 8.0 64.0 (None) Data Table
Other CA3 projecting hippocampus Granule Cell spike width (ms) 1.3 ± 0.2 1.3 (ms) Data Table
Other CA3 projecting hippocampus Granule Cell spike max rise slope (V/s) 272.0 ± 55.0 272.0 (mV/ms) Data Table
Other CA3 projecting hippocampus Granule Cell spike max decay slope (V/s) -124.0 ± 21.0 124.0 (mV/ms) Data Table
Other CA3 projecting hippocampus Granule Cell fast AHP amplitude (mV) 10.4 ± 3.1 10.4 (mV) Data Table
Other CA3 projecting hippocampus Granule Cell other 3.1 ± 1.1 3.1 (None) Data Table
Other CA3 projecting hippocampus Granule Cell resting membrane potential (mV) -70.0 ± 6.0 -70.0 (mV) Data Table