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Article: Postnatal alterations of the inhibitory synaptic responses recorded from cortical pyramidal neurons in the Lis1/sLis1 mutant mouse.

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Valdés-Sánchez L; Escámez T; Echevarria D; Ballesta JJ; Tabarés-Seisdedos R; Reiner O; Martinez S; Geijo-Barrientos E
Mol. Cell. Neurosci., 2007


Table 1Electrophysiological parameters of pyramidal neurons recorded from WT and Lis1/sLis1 animals
P7P30
WTLis1/sLis1WTLis1/sLis1
Resting potential (mV)−60.6±2.5 (−52 −70) n=44−66.4±2.9 (−52 −69) n=29−65.4±2.4 (−54 −88) n=39−66.1±3.5 (−64 −75) n=27
Input resistance (MΩ)467±50.1 (88–1900) n=44614±73.9 (191–1700) n=29156±12.1 (47–399) n=39165±17.9 (52–526) n=27
a.p. amplitude (mV)66.2±1.7 (54.7–81.2) n=2368.7±2.3 (55.4–78.9) n=1178.4±1.5 (54.4–89.2) n=2580.0±1.9 (67.1–99.7) n=22
a.p. duration (ms)1.77±0.87 (1.22–2.38) n=231.66±0.13 (0.99–2.33) n=111.02±0.06 (0.57–2.14) n=250.86±0.04⁎ (0.47–1.15) n=22
Ahp amplitude (mV)17.0±1.27 (6.2–29.3) n=2315.5±1.33 (7.35–22.1) n=1112.6±1.70 (4.6–23.3) n=2515.4±1.78 (8.5–22.8) n=22
Action potential (a.p.) amplitude was measured with respect to the threshold potential, and action potential duration was measured at half amplitude. Input resistance was measured from the voltage deflection produced by small hyperpolarizing current pulses (e.g. Fig. 1) and the amplitude of the after-hyperpolarization (Ahp) was measured from the threshold level to the most negative peak. Input resistance was calculated from responses to small hyperpolarizing current pulses. The mean±s.e.m., the range (in parenthesis), and the number of observations are provided for each parameter.⁎p<0.05 compared with P30, WT.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons resting membrane potential (mV) -65.4 ± 2.4 (39) -65.4 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons input resistance (MΩ) 467.0 ± 50.1 (44) 467.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons input resistance (MΩ) 156.0 ± 12.1 (39) 156.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons spike amplitude (mV) 66.2 ± 1.7 (44) 66.2 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons spike amplitude (mV) 78.4 ± 1.5 (39) 78.4 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons spike half-width (ms) 1.77 ± 0.87 (44) 1.77 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons spike half-width (ms) 1.02 ± 0.06 (39) 1.02 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons AHP amplitude (mV) 17.0 ± 1.27 (44) 17.0 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons AHP amplitude (mV) 12.6 ± 1.7 (39) 12.6 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Layer 2/3 frontal and parietal cortex pyramidal neurons resting membrane potential (mV) -60.6 ± 2.5 (44) -60.6 (mV) Data Table