Article: Tetanus toxin induces long-term changes in excitation and inhibition in the rat hippocampal CA1 area.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Vreugdenhil M; Hack SP; Draguhn A; Jefferys JG Neuroscience, 2002
Table 1Overview of intrinsic cellular properties of CA1 pyramidal neurones
For methods of quantification, see text and Fig. 1. Data are given as mean±S.E.M. P values for effect of experimental group (toxin and control) obtained from GLM analysis with rats ‘nested’ within the experimental groups.
Saline | Toxin | P | ||
n=25 | n=22 | |||
Passive properties | ||||
Resting membrane potential | (mV) | −62.3±0.9 | −61.6±1.2 | n.s. |
Input resistance | (MΩ) | 33.3±1.6 | 32.3±2.4 | n.s. |
Membrane capacitance | (pF) | 43.4±3.2 | 39.1±3.7 | n.s. |
First action potential evoked by a 0.1-s current injection | ||||
Depolarising pre-potential | (mV) | 3.9±0.5 | 2.8±0.7 | n.s. |
Action potential threshold | (mV) | −52.2±0.9 | −50.2±0.6 | n.s. |
Action potential amplitude | (mV) | 78.6±2.0 | 71.6±1.8 | <0.01 |
Maximum rate of rise | (V s−1) | 330±28 | 223±8 | <0.001 |
Maximum repolarisation rate | (V s−1) | 108±4 | 98±4 | <0.05 |
Fast AHP amplitude | (mV) | 10.8±0.4 | 7.3±0.5 | <0.01 |
Late AHP induced by a 0.1-s 1.4-nA current injection | ||||
Number of action potentials | 7.0±0.3 | 7.8±0.3 | n.s. | |
Medium AHP amplitude | (mV) | 5.2±0.7 | 3.7±0.4 | n.s. |
Slow AHP amplitude | (mV) | 3.7±0.5 | 1.7±0.4 | <0.01 |