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Article: Presynaptic homeostatic plasticity rescues long-term depression after chronic Delta 9-tetrahydrocannabinol exposure.

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Mato S; Robbe D; Puente N; Grandes P; Manzoni OJ
J. Neurosci., 2005


Table 1.

Repeated exposure to THC does not alter the basic electrophysiological properties of NAc core MSNs

Sham (n = 8) 7 d THC (n = 11) p
Resting membrane potential (mV) -83.6 -84.5 0.78
Membrane input resistance (M立) 269.8 221.3 0.40
Inward rectification (M立) 150.8 119.8 0.45
Membrane decay time constant (ms) 22.2 20.3 0.68
SAG amplitude (mV) 1.22 1.38 0.67
Firing threshold (mV) -44.7 -43.9 0.69
First spike amplitude (mV) 73.1 75.5 0.39
First spike AHP amplitude (mV) 11.9 11.2 0.85
Latency of first spike AHP (ms) 10.7 9.4 0.14

  • Detailed comparison of passive membrane properties and discharge properties of MSNs revealed no difference between sham and THC-treated mice (p value is given for each parameter analyzed).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron other 150.8 (8) 150.8 (None) Data Table
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron membrane time constant (ms) 22.2 (8) 22.2 (ms) Data Table
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron sag amplitude (mV) 1.22 (8) 1.22 (mV) Data Table
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron resting membrane potential (mV) -83.6 (8) -83.6 (mV) Data Table
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron spike threshold (mV) -44.7 (8) -44.7 (mV) Data Table
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron spike amplitude (mV) 73.1 (8) 73.1 (mV) Data Table
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron AHP amplitude (mV) 11.9 (8) 11.9 (mV) Data Table
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron AHP duration (ms) 10.7 (8) 10.7 (ms) Data Table
Nucleus accumbens medium spiny neuron nucleus accumbens core medium spiny neuron input resistance (MΩ) 269.8 (8) 269.8 (MΩ) Data Table