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Article: Neuronal differentiation in the adult hippocampus recapitulates embryonic development.

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Espósito MS; Piatti VC; Laplagne DA; Morgenstern NA; Ferrari CC; Pitossi FJ; Schinder AF
J. Neurosci., 2005


Table 1.

Membrane properties of neurons at discrete stages of maturation

Silent GABA GABA and glu GFP− neurons
Vrest (mV) − 50.6 ± 2.3 (37) − 45.6 ± 2.3 (24)* − 63.2 ± 2.8 (24)*** − 74.3 ± 0.7 (118)
Cm (pF) 6.4 ± 0.4 (42) 11.7 ± 1.2 (24)* 24.6 ± 1.4 (24)*** 38.8 ± 1.2 (126)
Rinput (MΩ) 4.3 ± 0.5 (42) 2.9 ± 0.4 (24)** 0.62 ± 0.10 (24)** 0.31 ± 0.14 (126)
Gm/Cm (pS/pF)a 65 ± 8 (42) 54 ± 8 (24)** 110 ± 19 (24) 111 ± 6 (126)
AP peak (mV)b 17.0 ± 1.7 (41) 43.8 ± 3.7 (23)** 83.5 ± 3.1 (24) 92.9 ± 1.2 (98)
Peak/in (nA)c − 0.17 ± 0.03 (36) − 1.04 ± 0.30 (24)*** − 4.2 ± 0.5 (23) − 5.4 ± 0.3 (98)
Maximum/out (nA)d 0.72 ± 0.05 (39)* 1.5 ± 0.2 (24)** 3.4 ± 0.3 (23) 3.8 ± 0.2 (98)

  • Data from GFP+ neurons were grouped by afferent connectivity and correspond to those in Figure 2 (silent), Figure 4 (GABA), and Figures 6, 7, 8 (GABA and glu). The GFP− neuron group summarizes values obtained from unlabeled neurons recorded between 1 and 29 dpi. Values are mean ± SEM. The number of cells tested is indicated in parentheses. Differences between groups were analyzed using a Kruskal-Wallis test followed by a post hoc Dunn's test to compare each group with its neighbor on the right. *p < 0.05; **p < 0.01; ***p < 0.001. AP, Action potential; Gm, membrane conductance.

  • ↵ a Provides a measure of the density of the leak conductance.

  • ↵ b Measured in the first action potential of the spike train.

  • ↵ c Inward current measured at Vhold = − 20 mV.

  • ↵ d Outward current measured at steady state (Vhold = + 70 mV).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Unlabelled Neurons cell capacitance (pF) 38.8 ± 1.2 (126) 38.8 (pF) Data Table
Other Dentate Gyrus Cell input resistance (MΩ) 4.3 ± 0.5 (42) -- Data Table
Other Dentate Gyrus Cell input resistance (MΩ) 2.9 ± 0.4 (24) -- Data Table
Other Dentate Gyrus Cell input resistance (MΩ) 0.62 ± 0.1 (24) 620.0 (MΩ) Data Table
Other Unlabelled Neurons input resistance (MΩ) 0.31 ± 0.14 (126) 310.0 (MΩ) Data Table
Other Dentate Gyrus Cell other (pS/pF) 65.0 ± 8.0 (42) 65.0 (None) Data Table
Other Dentate Gyrus Cell other (pS/pF) 54.0 ± 8.0 (24) 54.0 (None) Data Table
Other Dentate Gyrus Cell other (pS/pF) 110.0 ± 19.0 (24) 110.0 (None) Data Table
Other Dentate Gyrus Cell resting membrane potential (mV) -50.6 ± 2.3 (37) -50.6 (mV) Data Table
Other Unlabelled Neurons other (pS/pF) 111.0 ± 6.0 (126) 111.0 (None) Data Table
Other Dentate Gyrus Cell spike peak (mV) 17.0 ± 1.7 (41) 17.0 (mV) Data Table
Other Dentate Gyrus Cell spike peak (mV) 43.8 ± 3.7 (23) 43.8 (mV) Data Table
Other Dentate Gyrus Cell spike peak (mV) 83.5 ± 3.1 (24) 83.5 (mV) Data Table
Other Unlabelled Neurons spike peak (mV) 92.9 ± 1.2 (98) 92.9 (mV) Data Table
Other Dentate Gyrus Cell other (nA) -0.17 ± 0.03 (36) 0.17 (None) Data Table
Other Dentate Gyrus Cell other (nA) -1.04 ± 0.3 (24) 1.04 (None) Data Table
Other Dentate Gyrus Cell other (nA) -4.2 ± 0.5 (23) 4.2 (None) Data Table
Other Dentate Gyrus Cell resting membrane potential (mV) -45.6 ± 2.3 (24) -45.6 (mV) Data Table
Other Unlabelled Neurons other (nA) -5.4 ± 0.3 (98) 5.4 (None) Data Table
Other Dentate Gyrus Cell other (nA) 0.72 ± 0.05 (39) 0.72 (None) Data Table
Other Dentate Gyrus Cell other (nA) 1.5 ± 0.2 (24) 1.5 (None) Data Table
Other Dentate Gyrus Cell other (nA) 3.4 ± 0.3 (23) 3.4 (None) Data Table
Other Unlabelled Neurons other (nA) 3.8 ± 0.2 (98) 3.8 (None) Data Table
Other Dentate Gyrus Cell resting membrane potential (mV) -63.2 ± 2.8 (24) -63.2 (mV) Data Table
Other Unlabelled Neurons resting membrane potential (mV) -74.3 ± 0.7 (118) -74.3 (mV) Data Table
Other Dentate Gyrus Cell cell capacitance (pF) 6.4 ± 0.4 (42) 6.4 (pF) Data Table
Other Dentate Gyrus Cell cell capacitance (pF) 11.7 ± 1.2 (24) 11.7 (pF) Data Table
Other Dentate Gyrus Cell cell capacitance (pF) 24.6 ± 1.4 (24) 24.6 (pF) Data Table