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Article: Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion.

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Drew LJ; Stark KL; Fénelon K; Karayiorgou M; Macdermott AB; Gogos JA
Mol. Cell. Neurosci., 2011


Table 1Intrinsic properties of CA1 pyramidal neurons.
Rest pot (mV)Input res. (MΩ)Capacitance (pF)AP threshold (mV)Rheobase (pA)Voltage sag
WT−64.1±1.1 (16)147.8±11.8 (16)107.1±4.9 (16)−45.4±0.7 (13)88.13±8.27 (7)0.86±0.01 (16)
Df(16)A+/−−62.7±0.9 (16)156.1±9.8 (16)110.4±5.5 (16)−46.2±0.4 (12)91.25±14.41 (6)0.85±0.01 (16)
p0.300.590.650.340.850.89

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell input resistance (MΩ) 147.8 ± 11.8 (16) 147.8 (MΩ) Data Table
Hippocampus CA1 pyramidal cell cell capacitance (pF) 107.1 ± 4.9 (16) 107.1 (pF) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -45.4 ± 0.7 (13) -45.4 (mV) Data Table
Hippocampus CA1 pyramidal cell rheobase (pA) 88.13 ± 8.27 (7) 88.13 (pA) Data Table
Hippocampus CA1 pyramidal cell sag ratio 0.86 ± 0.01 (16) 0.86 (ratio) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -64.1 ± 1.1 (16) -64.1 (mV) Data Table