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Article: Opioids inhibit lateral amygdala pyramidal neurons by enhancing a dendritic potassium current.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Faber ES; Sah P J. Neurosci., 2004
Table 1.
Effects of potassium channel blockers and opioids on cell firing properties
| Control | α-DTX | Tityustoxin | DTX-K | Morphine | DAMGO | TEA | |
|---|---|---|---|---|---|---|---|
| Membrane potential (mV) | -63 ± 1 | -59 ± 1.3 | -58 ± 1.5 | -61 ± 1.1 | -62 ± 1.8 | -63 ± 1.6 | -66 ± 1.8 |
| Input resistance (MΩ) | 141 ± 7 | 119 ± 18 | 163 ± 28 | 128 ± 11 | 152 ± 14 | 145 ± 11 | 137 ± 16 |
| Spike half-width (msec) | 1.1 ± 0.04 | 1.1 ± 0.05 | 1.0 ± 0.03 | 1.1 ± 0.03 | 0.9 ± 0.1 | 1.1 ± 0.03 | 2.1 ± 0.1** |
| Spike initiation threshold (mV) | -33 ± 0.7 | -37 ± 2.5 | -30 ± 1.5 | -36 ± 2.0 | -37 ± 1.2 | -34 ± 2.5 | -41 ± 2** |
| Number of spikes fired | 5.0 ± 0.6 | 12.5 ± 2* | 9.7 ± 3* | 3 ± 1.2 | 1.7 ± 0.3** | 2.4 ± 0.6* | 2.6 ± 0.7** |
| AHP area (mV/sec) | 5.3 ± 0.8 | 3.8 ± 1.1 | 5.6 ± 3 | 3.8 ± 1 | 4.8 ± 3.1 | 3.9 ± 1 | 6.6 ± 2.2 |
| n | 49 | 8 | 3 | 3 | 10 | 11 | 14 |
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↵* p < 0.05; **p < 0.005 versus control. Control values are the average of all of the cells.
Inferred neuron-electrophysiology data values
| Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
|---|---|---|---|---|---|
| Lateral amygdala projection neuron | input resistance (MΩ) | 141.0 ± 7.0 (49) | 141.0 (MΩ) | Data Table | |
| Lateral amygdala projection neuron | spike half-width (msec) | 1.1 ± 0.04 (49) | 1.1 (ms) | Data Table | |
| Lateral amygdala projection neuron | resting membrane potential (mV) | -63.0 ± 1.0 (49) | -63.0 (mV) | Data Table | |
| Lateral amygdala projection neuron | spike threshold (mV) | -33.0 ± 0.7 (49) | -33.0 (mV) | Data Table |