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Article: Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) McDermott CM; LaHoste GJ; Chen C; Musto A; Bazan NG; Magee JC J. Neurosci., 2003
Somatic membrane properties of CA1 pyramidal neurons
| Rat | Vm (mV) | Rinω (M&OHgr;) | AP thresh (mV) | AP ampl (mV) | AP width (msec) | fAHP ampl (mV) | fAHP dur (msec) | mAHP ampl (mV) | mAHP dur (msec) | Adapt (msec) | Cort (ng/ml) n = 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP (19) | -62 ± 1 | 52 ± 3* | -51 ± 1 | 90 ± 5 | 0.8 ± 0.02 | 8.9 ± 2 | 4.1 ± 0.1 | 1.3 ± 0.2 | 249 ± 55 | 73 ± 8 | 211 ± 33* |
| Control (25) | -63 ± 1 | 69 ± 3 | -53 ± 1 | 92 ± 4 | 0.8 ± 0.02 | 8.6 ± 1 | 4.8 ± 0.5 | 1.2 ± 0.1 | 190 ± 36 | 43 ± 4* | 87 ± 21 |
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Vm′ Resting membrane potential; Rin′ input resistance; AP, action potential; thresh, threshold; ampl, amplitude from Vm′ width at half-maximum amplitude; fAHP ampl, fast afterhyperpolarization peak amplitude from Vm′. dur, duration at half-maximum amplitude; mAHP, medium afterhyperpolariztion; adapt, spike frequency adaptation as mean spike interval during last 350 msec of 700 msec current injection; Cort, plasma corticosterone concentration. *p<0.01.