Article: Antiepileptic efficacy of topiramate: assessment in two in vitro seizure models.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Jahromi SS; Pelletier MR; McDonald PJ; Khosravani H; Carlen PL Brain Res., 2000
Table 1Topiramate does not affect intrinsic membrane propertiesin CA1 pyramidal neuronsa
aNumber in parentheses denotes number of neurons.
Variable | Control | Topiramate (100 μM) |
Resting membrane potential (mV) | −62.3±1.8 | −61.8±2.1 |
(10) | (12) | |
Input resistance (MΩ) | 47.8±12.7 | 56.2±15.3 |
(10) | (12) | |
Spike amplitude (mV) | 106.3±2.8 | 107.4±2.9 |
(10) | (13) | |
Spike threshold (mV) | 40.6±1.6 | 39.0±1.7 |
(10) | (12) | |
Fast afterhyperpolarization (mV) | −13.9±0.9 | −11.9±0.9 |
(9) | (7) | |
Slow afterhyperpolarization (mV) | −11.3±0.8 | −9.5±1.2 |
(9) | (7) | |
Afterdepolarization (mV) | 11.8±0.8 | 11.1±1.4 |
(10) | (12) |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Hippocampus CA1 pyramidal cell | Hippocampus CA1 pyramidal neuron | input resistance (MΩ) | 47.8 ± 12.7 (10) | 47.8 (MΩ) | Data Table |
Hippocampus CA1 pyramidal cell | Hippocampus CA1 pyramidal neuron | spike amplitude (mV) | 106.3 ± 2.8 (10) | 106.3 (mV) | Data Table |
Hippocampus CA1 pyramidal cell | Hippocampus CA1 pyramidal neuron | spike threshold (mV) | 40.6 ± 1.6 (10) | -40.6 (mV) | Data Table |
Hippocampus CA1 pyramidal cell | Hippocampus CA1 pyramidal neuron | fast AHP amplitude (mV) | -13.9 ± 0.9 (10) | 13.9 (mV) | Data Table |
Hippocampus CA1 pyramidal cell | Hippocampus CA1 pyramidal neuron | slow AHP amplitude (mV) | -11.3 ± 0.8 (10) | 11.3 (mV) | Data Table |
Hippocampus CA1 pyramidal cell | Hippocampus CA1 pyramidal neuron | ADP amplitude (mV) | 11.8 ± 0.8 (10) | 11.8 (mV) | Data Table |
Hippocampus CA1 pyramidal cell | Hippocampus CA1 pyramidal neuron | resting membrane potential (mV) | -62.3 ± 1.8 (10) | -62.3 (mV) | Data Table |