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Article: Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Gao WJ; Wang Y; Goldman-Rakic PS
J. Neurosci., 2003


Table 1.

Properties of IPSPs and presynaptic interneurons in dual recording from PFC inhibitory circuits1-a

IPSP or interneuron properties FS (n = 18) Non-FS (n = 12)
Control DA Control DA
Amplitude (mV) −0.69  ± 0.10 −0.39  ± 0.051-160 −0.30  ± 0.051-170 −0.42  ± 0.06*
(−38.6%  ± 5.30) (+44.7%  ± 9.55)
20–80% rise time (msec) 3.44  ± 0.54 3.89  ± 0.66 6.77  ± 1.111-164 7.19  ± 1.84
Failure rate (%) 11.9  ± 2.50 33.4  ± 6.051-160 34.6  ± 4.371-170 27.5  ± 3.77
Normalized paired-pulse ratio (%) 100 127.7  ± 17.411-b,1-165 100 103.6  ± 5.23
 (n = 13)  (n = 13) (n = 5) (n = 5)
CV 0.43  ± 0.04 0.60  ± 0.041-165 0.59  ± 0.041-170 0.54  ± 0.03
Latency (msec) 0.86  ± 0.09 0.93  ± 0.11 0.76  ± 0.10 0.82  ± 0.07
Decay (τ, msec) 65.7  ± 9.84 57.6  ± 8.37 53.9  ± 6.81 55.5  ± 9.58
Membrane potential of interneuron (mV) −66.4  ± 1.01 −59.4  ± 1.481-160 −72.4  ± 2.37† −68.4  ± 2.311-160
Threshold of interneuron (mV) −43.1  ± 1.21 −44.1  ± 0.88 −51.6  ± 1.201-170 −52.7  ± 1.76
Reversal potential (mV) −69.3  ± 0.89 −71.1  ± 0.92
AHP of interneuron action potential (mV) 14.0  ± 0.67 11.2  ± 0.661-164
Half-width of interneuron action potential (msec) 0.53  ± 0.03 0.64  ± 0.04†
Input resistance of interneuron (MΩ) 72.5  ± 11.62 63.8  ± 15.35
Membrane potential of pyramidal neuron (mV) 61.0  ± 1.12 60.4  ± 1.46 59.8  ± 1.40 58.2  ± 0.59

  • ↵F1-a All data are presented as means ± SE.

  • ↵F1-b  Average of both PPD and PPF.

  • ↵* p < 0.05,

  • ↵F1-160 p < 0.01,

  • ↵F1-165 p < 0.001 between control and DA within group.

  • ↵† p < 0.05,

  • ↵F1-164 p < 0.01,

  • ↵F1-170 p < 0.001 between FS NP-P and non-FS NP-P group under control conditions.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell resting membrane potential (mV) -66.4 ± 1.01 -66.4 (mV) Data Table
Neocortex basket cell spike threshold (mV) -43.1 ± 1.21 -43.1 (mV) Data Table
Neocortex basket cell spike half-width (msec) 0.53 ± 0.03 0.53 (ms) Data Table
Neocortex basket cell input resistance (MΩ) 72.5 ± 11.62 72.5 (MΩ) Data Table