TABLE 1.Intrinsic membrane and action potential properties (P10–P29)
|
|
|||||
| Property | Age, Days |
||||
| P10–P14 (n = 56) | P15–P18 (n = 66) | P19–P29 (n = 66) | |||
|
|
|||||
| Rn, MΩ | 306 ± 76 | 244 ± 64** | 139 ± 34**†† | ||
| τm, ms | 38 ± 9 | 26 ± 7** | 15 ± 5**†† | ||
| Vm, mV | –70 ± 6 | –75 ± 6** | –81 ± 5**†† | ||
| HW, ms | 1.9 ± 0.5 | 1.8 ± 0.5 | 1.2 ± 0.3**†† | ||
| AHP, mV | 16 ± 2 | 14 ± 3** | 12 ± 3**†† | ||
| Height, mV | 52 ± 9 | 48 ± 16 | 54 ± 10 | ||
| Rheobase, nA | 0.07 ± 0.06 | 0.10 ± 0.06** | 0.26 ± 0.09**†† | ||
| Threshold, mV | –37 ± 4 | –37 ± 5 | –37 ± 5 | ||
Values are means ± SD. Rn, input resistance; τm, membrane time constant; Vm, resting membrane potential; HW, action potential width at half maximum; AHP, afterhyperpolarization. Significance:
** P < 0.01 for adjacent columns (i.e., P10–P14 vs. P15–P18 and P15–P18 vs. P19–P29);
†† P < 0.01 for P10–P14 versus P19–P29.