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Article: Excitatory role of the hyperpolarization-activated inward current in phasic and tonic firing of rat supraoptic neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Ghamari-Langroudi M; Bourque CW J. Neurosci., 2000
Effects of ZD 7288 on parameters influencing cell excitability
| n | Control | ZD 7288 | p value | |
|---|---|---|---|---|
| AP parameters | ||||
| AP overshoot (absolute voltage; in mV) | 5 | 20.2 ± 6.03 | 17.4 ± 6.20 | 0.0407 |
| AP duration (at half-amplitude; in msec) | 5 | 0.96 ± 0.10 | 1.20 ± 0.20 | 0.164 |
| HAP amplitude (absolute voltage; in mV) | 5 | −70.7 ± 3.7 | −70.5 ± 2.5 | 0.933 |
| DAP amplitude (from baseline; in mV) | 5 | 3.6 ± 0.5 | 3.5 ± 0.4 | 0.486 |
| Threshold current (pA) | 7 | 120.7 ± 20.7 | 127.9 ± 25.1 | 0.587 |
| Synaptic parameters | ||||
| sEPSP frequency (Hz) | 4 | 0.33 ± 0.12 | 0.29 ± 0.14 | 0.371 |
| Median sEPSP amplitude (mV) | 4 | 2.31 ± 1.09 | 1.81 ± 0.66 | 0.347 |
| sIPSP frequency (Hz) | 6 | 2.18 ± 0.61 | 2.19 ± 0.54 | 0.973 |
| Median sIPSP amplitude (mV) | 6 | −3.19 ± 0.86 | −3.37 ± 0.76 | 0.435 |
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The table reports mean (±SEM) values of various action potential (AP) and synaptic parameters. AP parameters were specifically evaluated in cells in which constant numbers of APs were evoked by brief (20–80 msec) current pulses delivered at very low frequencies (2–3 per min), from a constant initial V m. Synaptic potential parameters were specifically evaluated in cells held at a constant potential between −61 and −57 mV, using procedures described in Materials and Methods.