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Article: Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons.

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Bonin RP; Martin LJ; MacDonald JF; Orser BA
J. Neurophysiol., 2007



TABLE 1.Action potential characteristics
WT (10) α5–/– (10) P Value
Peak amplitude, mV 74.9 ± 2.6 81.6 ± 2.6 0.172
Half-width, ms 1.40 ± 0.10 1.62 ± 0.12 0.220
Action potential threshold, mV –41.6 ± 1.6 –42.0 ± 0.9 0.767
AHP amplitude, mV –16.9 ± 1.6 –14.9 ± 1.6 0.628
Maximum rise slope, mV ms–1 201.9 ± 20.6 198.3 ± 24.1 0.952
Maximum decay slope, mV ms–1 –69.3 ± 6.7 –57.2 ± 4.4 0.181
Properties of action potentials measured from cultured type (WT) and α5–/– pyramidal neurons. Values are means ± SE. Parentheses enclose n values.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.4 ± 0.1 (10) 1.4 (ms) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -41.6 ± 1.6 (10) -41.6 (mV) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude (mV) -16.9 ± 1.6 (10) 16.9 (mV) Data Table
Hippocampus CA1 pyramidal cell spike max rise slope 201.9 ± 20.6 (10) 201.9 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell spike max decay slope -69.3 ± 6.7 (10) 69.3 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 74.9 ± 2.6 (10) 74.9 (mV) Data Table