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Article: Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex.

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González-Burgos G; Krimer LS; Urban NN; Barrionuevo G; Lewis DA
Cereb. Cortex, 2004


Table 1


 Intrinsic membrane properties of layer 3 neurons in monkey DLPFC

Regular spiking Fast spiking Adapting non-pyramidal
Resting membrane potential -74.4 ± 1.1 mV, n = 20 -67.7 ± 1.2 mV, n = 20 -68.2 ± 1.3 mV, n = 17
Input resistance 102.4 ± 22.0 MΩ, n = 14 165.8 ± 15.0 MΩ, n = 20 291.4 ± 31.0 MΩ, n = 17
Time constant  22.3 ± 3.6 ms, n = 14   9.5 ± 0.8 ms, n = 15  24.4 ± 1.82 ms, n = 14
AHP amplitude  11.4 ± 1.1 mV, n = 18  27.0 ± 2.2 mV, n = 19  21.3 ± 1.5 mV, n = 17
Spike width at half amplitude  1.05 ± 0.08 ms, n = 20  0.39 ± 0.03 ms, n = 20  0.68 ± 0.08 ms, n = 17

All of the differences between group means were significant (P < 0.02; one-way ANOVA followed by comparisons with Tukey’s test) except the difference between resting membrane potential of FS and ANP cells and between time constant of RS and ANP neurons. AHP: after hyperpolarizing potential.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal regular spiking neurons input resistance 102.4 ± 22.0 (18) 102.4 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal fast-spiking interneurons input resistance 165.8 ± 15.0 (20) 165.8 (MΩ) Data Table
Other Dorsolateral prefrontal cortex layer 3 adapting non-pyramidal interneurons input resistance 291.4 ± 31.0 (17) 291.4 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal regular spiking neurons membrane time constant 22.3 ± 3.6 (18) 22.3 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal fast-spiking interneurons membrane time constant 9.5 ± 0.8 (20) 9.5 (ms) Data Table
Other Dorsolateral prefrontal cortex layer 3 adapting non-pyramidal interneurons membrane time constant 24.4 ± 1.82 (17) 24.4 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal regular spiking neurons AHP amplitude 11.4 ± 1.1 (18) 11.4 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal fast-spiking interneurons AHP amplitude 27.0 ± 2.2 (20) 27.0 (mV) Data Table
Other Dorsolateral prefrontal cortex layer 3 adapting non-pyramidal interneurons AHP amplitude 21.3 ± 1.5 (17) 21.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal regular spiking neurons spike half-width (at) 1.05 ± 0.08 (18) -- Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal fast-spiking interneurons spike half-width (at) 0.39 ± 0.03 (20) -- Data Table
Other Dorsolateral prefrontal cortex layer 3 adapting non-pyramidal interneurons spike half-width (at) 0.68 ± 0.08 (17) -- Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal regular spiking neurons resting membrane potential -74.4 ± 1.1 (18) -74.4 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Dorsolateral prefrontal cortex layer 3 pyramidal fast-spiking interneurons resting membrane potential -67.7 ± 1.2 (20) -67.7 (mV) Data Table
Other Dorsolateral prefrontal cortex layer 3 adapting non-pyramidal interneurons resting membrane potential -68.2 ± 1.3 (17) -68.2 (mV) Data Table