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Article: Long-term IL-1β exposure causes subpopulation-dependent alterations in rat dorsal root ganglion neuron excitability.

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Stemkowski PL; Smith PA
J. Neurophysiol., 2012


Table 2.

Summary of effects of IL-1β exposure on DRG neuron AP parameters and passive membrane properties with IL-1Ra cotreatment

Parameter Medium Neuron IL-1Ra Medium Neuron IL-1β + IL-1Ra Small IB4+ Neuron IL-1Ra Small IB4+ Neuron IL-1β + IL-1Ra
RMP, mV −60.5 ± 0.9 (22) −61.8 ± 1.1 (25) −60.2 ± 1.4 (22) −62.5 ± 1.3 (21)
AP threshold, mV −29.6 ± 1.6 (19) −30.3 ± 1.3 (24) −23.1 ± 1.9 (22) −21.3 ± 2.6 (19)
Spike height, mV 100.2 ± 3.6 (22) 114.6 ± 2.9 (25)† 113.9 ± 3.0 (22)a 107.4 ± 2.9 (21)
Spike width, ms 1.85 ± 0.13 (22) 2.58 ± 0.26 (25)* 2.51 ± 0.21 (22)a 3.67 ± 0.87 (21)
Maximal rate of AP depolarization, mV/ms 109.3 ± 9.1 (22) 138.1 ± 7.6 (25)* 101.5 ± 5.7 (22) 106.5 ± 9.2 (21)
Maximal rate of AP repolarization, mV/ms −58.0 ± 3.9 (22) −54.3 ± 4.0 (25) −54.0 ± 3.6 (22) −44.5 ± 3.8 (21)
AHP amplitude, mV −15.5 ± 1.1 (22) −12.6 ± 1.2 (25) −16.7 ± 1.0 (22)a −15.8 ± 1.0 (21)
AHP duration at 25% repolarization, ms 14.53 ± 1.31 (22) 16.67 ± 1.76 (21) 25.28 ± 3.11 (22) 21.55 ± 2.26 (21)
AHP duration at 50% repolarization, ms 26.44 ± 3.08 (21)a 33.53 ± 3.42 (20) 39.45 ± 4.49 (15) 39.50 ± 4.57 (15)
Rheobase, nA 0.51 ± 0.04 (22) 0.40 ± 0.04 (25)* 0.36 ± 0.02 (22) 0.37 ± 0.03 (21)
Input resistance, MΩ 225 ± 18 (22)b 393 ± 36 (25)‡ 591 ± 31 (22)b 551 ± 41 (21)

  • Values are means ± SE (n in parentheses). Statistical significance determined with unpaired t-test. Significant difference vs. control:

  • ↵* P < 0.05,

  • ↵† P < 0.01,

  • ↵‡ P < 0.001.

  • ↵a Significant difference vs. control in Table 1: P < 0.05,

  • ↵b P < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell resting membrane potential (mV) -60.5 ± 0.9 (22) -60.5 (mV) Data Table
Dorsal root ganglion cell spike threshold (mV) -29.6 ± 1.6 (19) -29.6 (mV) Data Table
Dorsal root ganglion cell spike amplitude (mV) 100.2 ± 3.6 (22) 100.2 (mV) Data Table
Dorsal root ganglion cell spike width (ms) 1.85 ± 0.13 (22) 1.85 (ms) Data Table
Dorsal root ganglion cell AHP amplitude (mV) -15.5 ± 1.1 (22) 15.5 (mV) Data Table
Dorsal root ganglion cell rheobase (nA) 0.51 ± 0.04 (22) 510.0 (pA) Data Table
Dorsal root ganglion cell input resistance (MΩ) 225.0 ± 18.0 (22) 225.0 (MΩ) Data Table