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Article: Chronic compression of mouse dorsal root ganglion alters voltage-gated sodium and potassium currents in medium-sized dorsal root ganglion neurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Fan N; Donnelly DF; LaMotte RH
J. Neurophysiol., 2011


Table 1.

Membrane properties of control and CCD neurons measured in whole-cell patch-clamp experiments

n Diameter, μm Cm, pF Vm, mV Rin, MΩ AP Rheobase, pA AP VTH, mV AP Amplitude, mV AP Duration, ms MS/non-MS
Control 9 38.9 ± 2.1 48.9 ± 5.3 −61.2 ± 2.0 108.9 ± 19.9 627.8 ± 43.4 −26.2 ± 6.7 115.4 ± 7.7 1.5 ± 0.3 0/9
CCD 8 40.8 ± 1.4 52.7 ± 3.5 −58.9 ± 1.7 125.9 ± 19.6 456.3 ± 78.7* −35.1 ± 3.2 109.1 ± 7.8 1.2 ± 0.2 3/5
  • Values are mean ± SE. CCD, chronic compression; n, number of cells; Cm, cell capacitance; Vm, membrane potential; Rin, input resistance; AP, action potential; AP Rheobase, current threshold of AP; VTH, voltage threshold; MS, number of cells firing multiple (≥2) spikes to current step at 2× rheobase; non-MS, number of cells discharging 1 spike.

  • * P < 0.05 (Student's t-tests, significant differences between control and CCD).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell AHP duration (ms) 1.5 ± 0.3 1.5 (ms) Data Table
Dorsal root ganglion cell cell diameter (μm) 38.9 ± 2.1 38.9 (um) Data Table
Dorsal root ganglion cell cell capacitance (pF) 48.9 ± 5.3 48.9 (pF) Data Table
Dorsal root ganglion cell resting membrane potential (mV) -61.2 ± 2.0 -61.2 (mV) Data Table
Dorsal root ganglion cell input resistance (MΩ) 108.9 ± 19.9 108.9 (MΩ) Data Table
Dorsal root ganglion cell rheobase (pA) 627.8 ± 43.4 627.8 (pA) Data Table
Dorsal root ganglion cell spike threshold (mV) -26.2 ± 6.7 -26.2 (mV) Data Table
Dorsal root ganglion cell spike amplitude (mV) 115.4 ± 7.7 115.4 (mV) Data Table