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Article: Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increased responsiveness to cAMP and cGMP.

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Zheng JH; Walters ET; Song XJ
J. Neurophysiol., 2007



TABLE 1.Effects of dissociation and CCD treatment on membrane properties of small DRG neurons
Sham Intact Sham Dissociated CCD Intact CCD Dissociated
n 22 27 28 30
Diameter, µm 20.1 ± 1.6 20.9 ± 1.5 22.6 ± 1.2 24.0 ± 0.8
Rin, MΩ 416 ± 14 635 ± 12** 425 ± 15 651 ± 14**
Cin, pF 43.2 ± 1.1 35.5 ± 0.9** 41.2 ± 1.0 36.4 ± 0.7**
RMP, mV –55.9 ± 1.5 –49.8 ± 0.9** –50.3 ± 1.0** –49.2 ± 1.1**
AP current threshold (nA) 0.34 ± 0.04 0.12 ± 0.02** 0.07 ± 0.01** 0.08 ± 0.01**
AP voltage threshold, mV –27.2 ± 1.7 –27.7 ± 1.0 –27.9 ± 1.1 –29.6 ± 1.0
AP amplitude, mV 62.1 ± 1.0 59.6 ± 1.0 60.0 ± 0.8 58.8 ± 0.8
AP duration, ms 3.43 ± 0.28 4.65 ± 0.27* 4.58 ± 0.31* 4.65 ± 0.29*
AHP amplitude, mV 21.4 ± 3.5 24.9 ± 1.9 20.5 ± 3.1 27.6 ± 3.2
AHP duration, ms 13.6 ± 3.5 32.6 ± 5.2** 14.4 ± 2.6 36.2 ± 7.0**
Number of APs, 1-s pulse 2.05 ± 0.25 8.11 ± 1.57** 7.14 ± 1.19** 8.67 ± 1.34**
Neurons exhibiting SA# 0.0% 12.9%* 12.5%* 14.3%*
Values are means ± SE. Asterisks indicate significant differences from the sham intact group:

* , P < 0.05,

** , P < 0.01 (1-way ANOVA followed by pairwise comparisons using Newman-Keuls tests; comparisons of incidence (%) are by Fisher's exact test). n, number of dorsal rat ganglion (DRG) neurons tested; Rin, input resistance; Cin, input capacitance; RMP, resting membrane potential; AP, action potential; AHP, afterhyperpolarization; SA, spontaneous activity; CCD, chronic compression of the DRG. Number of APs monitors repetitive firing to a standardized 1-s depolarizing pulse.

# , SA neurons were not included in n, and were not included in any of the other data sets above.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell small dorsal root ganglion cell diameter 20.1 ± 1.6 (22) 20.1 (um) Data Table
Dorsal root ganglion cell small dorsal root ganglion input resistance (MΩ) 416.0 ± 14.0 (22) 416.0 (MΩ) Data Table
Dorsal root ganglion cell small dorsal root ganglion cell capacitance (pF) 43.2 ± 1.1 (22) 43.2 (pF) Data Table
Dorsal root ganglion cell small dorsal root ganglion resting membrane potential (mV) -55.9 ± 1.5 (22) -55.9 (mV) Data Table
Dorsal root ganglion cell small dorsal root ganglion rheobase (nA) 0.34 ± 0.04 (22) 340.0 (pA) Data Table
Dorsal root ganglion cell small dorsal root ganglion spike threshold (mV) -27.2 ± 1.7 (22) -27.2 (mV) Data Table
Dorsal root ganglion cell small dorsal root ganglion spike amplitude (mV) 62.1 ± 1.0 (22) 62.1 (mV) Data Table
Dorsal root ganglion cell small dorsal root ganglion spike width (ms) 3.43 ± 0.28 (22) 3.43 (ms) Data Table
Dorsal root ganglion cell small dorsal root ganglion AHP amplitude (mV) 21.4 ± 3.5 (22) 21.4 (mV) Data Table
Dorsal root ganglion cell small dorsal root ganglion AHP duration (ms) 13.6 ± 3.5 (22) 13.6 (ms) Data Table
Dorsal root ganglion cell small dorsal root ganglion firing frequency 2.05 ± 0.25 (22) 2.05 (Hz) Data Table