Article: Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice.
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Wu HM; Huang CC; Chen SH; Liang YC; Tsai JJ; Hsieh CL; Hsu KS
Eur. J. Neurosci., 2003
Table 1. Electrophysiological properties of hippocampal CA3 pyramidal neurons at 7-12 days post HSV-1 infection | Parameters | Control (n = 16) | Severe infection | Moderate infection | Mild infection |
|---|
| Regular (n = 1) | Grade-I (n = 4) | Grade-II (n = 5) | Regular (n = 4) | Grade-I (n = 7) | Grade-II (n = 5) | Regular (n = 4) | Grade-I (n = 2) | Grade-II (n = 1) |
|---|
| RMP (mV) | -70.6 ± 1.5 | -69 | -63.5 ± 2.3* | -61.2 ± 2.1* | -66.7 ± 2.8 | -64.2 ± 1.9* | -62.8 ± 1.7* | -71.2 ± 1.8 | -65.2 ± 1.1* | -62* |
| Input resistance (MΩ) | 72.6 ± 3.7 | 71.3 | 81.2 ± 1.8* | 88.9 ± 1.6* | 75.3 ± 2.3 | 82.1 ± 2.3* | 87.6 ± 2.5* | 69.8 ± 2.3 | 81.2 ± 1.2* | 89.5* |
| Spike threshold (mV) | -55.6 ± 1.6 | -54 | -54.6 ± 1.6 | -55.2 ± 1.8 | -56.3 ± 1.8 | -57.6 ± 1.9 | -53.6 ± 2.3 | -54.3 ± 1.9 | -56.2 ± 0.7 | -54 |
| Spike amplitude (mV) | 78.9 ± 1.4 | 78 | 76.5 ± 1.5 | 76.9 ± 1.6 | 80.6 ± 2.1 | 75.4.± 1.9 | 78.1 ± 1.9 | 82.3 ± 2.1 | 77.2 ± 0.6 | 77 |
| Vmax (mV/ms) | 225 ± 13 | 218 | 214 ± 18 | 216 ± 17 | 232 ± 21 | 213 ± 24 | 219 ± 25 | 238 ± 23 | 228 ± 6 | 221 |
| fAHP amplitude (mV) | 12.8 ± 1.9 | 10.2 | 6.9 ± 1.5* | 4.8 ± 1.3* | 10.9 ± 1.3 | 7.2 ± 1.9* | 5.1 ± 1.6* | 11.7 ± 1.6 | 7.2 ± 0.6* | 4.5* |
| sAHP amplitude (mV) | 7.8 ± 1.4 | 8.2 | 4.2 ± 1.4* | 2.5 ± 0.9* | 7.8 ± 1.6 | 4.3 ± 1.1* | 2.8 ± 1.1* | 8.7 ± 1.4 | 4.3 ± 0.5* | 2.8* |
Inferred neuron-electrophysiology data values
