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Article: Selective functional interactions between excitatory and inhibitory cortical neurons and differential contribution to persistent activity of the slow oscillation.

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Tahvildari B; Wölfel M; Duque A; McCormick DA
J. Neurosci., 2012


Table 1.

Membrane potential dynamics and properties of different excitatory and inhibitory neurons during slow oscillation

Parameters Neural types
A. Pyramidal B. Stellate C. FS D. NPY NGF E. NPY Non-NGF F. SOM G. 5HTR3a H. VIP
Mean firing rate during Up state (Hz) 4.2 ± 0.4B-H (0-7; 17) 0.6 ± 0.2A,C-E,G,H (0-2.5; 16) 9.1 ± 1.9A,B,D-H (0-45; 32) 0 (23)A-C,F 0 (9)A-C,F 0.7 ± 0.2A,C-E,G,H (0-4.2; 34/48) 0 (42)A-C,F 0 (19)A-C,F
Mean depolarization during Up state (mV) 8.5 ± 0.7B-H (3.5-15; 17) 2.5 ± 0.3A,C,D,G,H (1.1-4.9; 16) 12.3 ± 0.9A-B,D-H (3.2-25; 32) 6.2 ± 0.3A-C,E-H (4.1-8.9; 23) 2.6 ± 0.6A,C,D (0-4.6; 9) 2.2 ± 0.2A,C,D,G,H (0-4.8; 34/48) 1.4 ± 0.2A-D,F (0-3.6; 42) 1.0 ± 0.3A-D,F (0-4; 19)
Ge (nS) 0.63 ± 0.06C,F-H (0.26-0.98; 14) 0.55 ± 0.11C,F-H (0.2-1.19; 8) 1.35 ± 0.2A,B,D,F,G (0.3-2.64; 11) 0.46 ± 0.08C,F-H (0.3-0.69; 4) NA 0.14 ± 0.02A-D (0.1-0.19; 4) 0.15 ± 0.03A-D (0.07-0.23; 4) 0.11 ± 0.02A-D (0.06- 0.21; 7)
Gi (nS) 2.24 ± 0.31C,D,F-H (0.72-4.48; 14) 1.55 ± 0.18C,D,F-H (0.64-2.29; 8) 0.62 ± 0.12A,B,F (0.21-1.66; 11) 0.29 ± 0.07A,B,F (0.1-0.39; 4) NA 0.09 ± 0.005A-D,G,H (0.08-0.1; 4) 0.56 ± 0.1A,B,F (0.29-0.8; 4) 0.35 ± 0.08A,B,F (0.18-0.72; 7)
RMP (mV) -75.4 ± 0.7B,C,F-H (-82 to -70; 17) -72.3 ± 0.6A,C,D (-78 to -68; 16) -78.5 ± 0.6A,B,D-H (-86 to -70; 32) -75.5 ± 0.8B,C,F-H (-80 to -62; 23) -74.1 ± 1.4C,F (-82 to -68; 9) -70.7 ± 0.5A,C-E (-76 to -66; 32) -71.7 ± 0.5A,C,D (-80 to -63; 42) -71.4 ± 0.8A,C,D (-76 to -63; 19)
Action potential threshold (mV) -53.8 ± 0.4C,D,F-H (-56 to -51; 17) -52.8 ± 0.8C,D,G,H (-43 to -58; 16) -48.1 ± 0.6A,B,D-F,H (-53 to -43; 32) -43.5 ± 0.6A-C,E-G (-49 to -38; 23) -52.0 ± 1.1C,D,G,H (-56 to -46; 9) -51.4 ± 0.5A,C,D,G,H (-56 to -43; 32) -48.6 ± 0.5A,B,D,E,F,H (-54 to -43; 42) -43.7 ± 0.5A-C,E-G (-48 to -40; 19)
Input resistance (MΩ) 243 ± 3B,C,E-H (125-400; 17) 149 ± 16A,D-H (80-260; 16) 156 ± 8A,D-H (60-250; 32) 206 ± 11B,C,E-H (130-340; 23) 385 ± 58A-D (200-720; 9) 452 ± 28A-D (190-800; 32) 403 ± 28A-D,H (200-800; 42) 508 ± 43A-D,G (250-900; 19)
  • Values are reported in mean ± SE. Statistical differences between different neurons are reported in superscript alphabet at p < 0.05; numbers in parentheses indicate the range and the numbers of recorded neurons, respectively. Ge and Gi, Excitatory and inhibitory conductances, respectively. RMP, Resting membrane potential.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layer 2/3 pyramidal EGFP-positive excitatory neurons firing frequency (Hz) 4.2 ± 0.4 (17) 4.2 (Hz) Data Table
Medial entorhinal cortex layer II stellate cell Entorhinal cortex layer 2/3 stellate EGFP-positive excitatory neurons firing frequency (Hz) 0.6 ± 0.2 (16) 0.6 (Hz) Data Table
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layer 2/3 pyramidal EGFP-positive excitatory neurons resting membrane potential (mV) -75.4 ± 0.7 (17) -75.4 (mV) Data Table
Medial entorhinal cortex layer II stellate cell Entorhinal cortex layer 2/3 stellate EGFP-positive excitatory neurons resting membrane potential (mV) -72.3 ± 0.6 (16) -72.3 (mV) Data Table
Other Entorhinal cortex layer 2/3 fast-spiking EGFP-positive GABAergic inhibitory interneurons firing frequency (Hz) 9.1 ± 1.9 (32) 9.1 (Hz) Data Table
Other Entorhinal cortex layer 2/3 fast-spiking EGFP-positive GABAergic inhibitory interneurons resting membrane potential (mV) -78.5 ± 0.6 (32) -78.5 (mV) Data Table
Other Entorhinal cortex layer 2/3 neuropeptide Y-postive EGFP-positive neurogliaform interneurons resting membrane potential (mV) -75.5 ± 0.8 (32) -75.5 (mV) Data Table
Other Entorhinal cortex layer 2/3 neuropeptide Y-postive EGFP-positive non-neurogliaform interneurons resting membrane potential (mV) -74.1 ± 1.4 -74.1 (mV) Data Table
Other Entorhinal cortex layers 2/3 somatostatin-expressing EGFP-positive interneurons resting membrane potential (mV) -70.7 ± 0.5 (48) -70.7 (mV) Data Table
Other Entorhinal cortex layer 2/3 5HT3a receptor containing EGFP-positive interneurons resting membrane potential (mV) -71.7 ± 0.5 (42) -71.7 (mV) Data Table
Other Entorhinal cortex layer 2/3 vasoactive intestinal peptide-positive Zs-green-expressing interneurons resting membrane potential (mV) -71.4 ± 0.8 (19) -71.4 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layer 2/3 pyramidal EGFP-positive excitatory neurons spike threshold (mV) -53.8 ± 0.4 (17) -53.8 (mV) Data Table
Medial entorhinal cortex layer II stellate cell Entorhinal cortex layer 2/3 stellate EGFP-positive excitatory neurons spike threshold (mV) -52.8 ± 0.8 (16) -52.8 (mV) Data Table
Other Entorhinal cortex layer 2/3 fast-spiking EGFP-positive GABAergic inhibitory interneurons spike threshold (mV) -48.1 ± 0.6 (32) -48.1 (mV) Data Table
Other Entorhinal cortex layer 2/3 neuropeptide Y-postive EGFP-positive neurogliaform interneurons spike threshold (mV) -43.5 ± 0.6 (32) -43.5 (mV) Data Table
Other Entorhinal cortex layer 2/3 neuropeptide Y-postive EGFP-positive non-neurogliaform interneurons spike threshold (mV) -52.0 ± 1.1 -52.0 (mV) Data Table
Other Entorhinal cortex layers 2/3 somatostatin-expressing EGFP-positive interneurons spike threshold (mV) -51.4 ± 0.5 (48) -51.4 (mV) Data Table
Other Entorhinal cortex layer 2/3 5HT3a receptor containing EGFP-positive interneurons spike threshold (mV) -48.6 ± 0.5 (42) -48.6 (mV) Data Table
Other Entorhinal cortex layer 2/3 vasoactive intestinal peptide-positive Zs-green-expressing interneurons spike threshold (mV) -43.7 ± 0.5 (19) -43.7 (mV) Data Table
Medial entorhinal cortex layer III pyramidal cell Entorhinal cortex layer 2/3 pyramidal EGFP-positive excitatory neurons input resistance (MΩ) 243.0 ± 3.0 (17) 243.0 (MΩ) Data Table
Medial entorhinal cortex layer II stellate cell Entorhinal cortex layer 2/3 stellate EGFP-positive excitatory neurons input resistance (MΩ) 149.0 ± 16.0 (16) 149.0 (MΩ) Data Table
Other Entorhinal cortex layer 2/3 fast-spiking EGFP-positive GABAergic inhibitory interneurons input resistance (MΩ) 156.0 ± 8.0 (32) 156.0 (MΩ) Data Table
Other Entorhinal cortex layer 2/3 neuropeptide Y-postive EGFP-positive neurogliaform interneurons input resistance (MΩ) 206.0 ± 11.0 (32) 206.0 (MΩ) Data Table
Other Entorhinal cortex layer 2/3 neuropeptide Y-postive EGFP-positive non-neurogliaform interneurons input resistance (MΩ) 385.0 ± 58.0 385.0 (MΩ) Data Table
Other Entorhinal cortex layers 2/3 somatostatin-expressing EGFP-positive interneurons input resistance (MΩ) 452.0 ± 28.0 (48) 452.0 (MΩ) Data Table
Other Entorhinal cortex layer 2/3 5HT3a receptor containing EGFP-positive interneurons input resistance (MΩ) 403.0 ± 28.0 (42) 403.0 (MΩ) Data Table
Other Entorhinal cortex layer 2/3 vasoactive intestinal peptide-positive Zs-green-expressing interneurons input resistance (MΩ) 508.0 ± 43.0 (19) 508.0 (MΩ) Data Table
Other Entorhinal cortex layers 2/3 somatostatin-expressing EGFP-positive interneurons firing frequency (Hz) 0.7 ± 0.2 (48) 0.7 (Hz) Data Table