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Article: Satb1 is an activity-modulated transcription factor required for the terminal differentiation and connectivity of medial ganglionic eminence-derived cortical interneurons.

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Close J; Xu H; De Marco García N; Batista-Brito R; Rossignol E; Rudy B; Fishell G
J. Neurosci., 2012


Table 1.

Comparison of membrane properties between wild-type SST INs or PV INs and surviving Satb1-/- SST INs or PV INs in layer 4 somatosensory cortex

SST INs PV INs
Wild type (n = 23) SSTCre;Satb1c/c (n = 18) Wild type (n = 12) Dlx5/6Cre;Satb1c/c (n = 12)
Resting membrane potential (mV) -65.3 ± 0.6 -65.9 ± 0.8 -70.8 ± 1.0 -69.7 ± 1.2
Membrane resistance (MΩ) 118.8 ± 7.1 174.2 ± 22.5* 71.3 ± 11.3 74.1 ± 11.1
τ (ms) 8.8 ± 0.4 16.2 ± 1.3** 8.2 ± 0.6 7.4 ± 0.6
Action potential threshold (pA) 204.4 ± 23.5 161.1 ± 20.4* 550 ± 69.9 535 ± 40.8
Action potential threshold (mV) -41.9 ± 0.8 -40.2 ± 0.9 -42.4 ± 2.6 -41.5 ± 1.8
Action potential height (mV) 64.9 ± 1.7 65.1 ± 1.6 60.7 ± 3.5 60.4 ± 3.1
Action potential width (ms) 0.41 ± 0.01 0.43 ± 0.02 0.23 ± 0.01 0.22 ± 0.01
Afterhyperpolarization (mV) 22.4 ± 0.8 22.4 ± 1.5
  • For an explanation of the parameters, see Materials and Methods. Values shown are expressed as mean ± SEM. Significant differences between mutant and wild-type values are expressed as significant difference from wild type (*p < 0.05; **p < 0.01; t test).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex Martinotti cell somatosensory cortex layer 4 medial ganglionic eminence-derived somatostatin-expressing interneurons membrane time constant (ms) 8.8 ± 0.4 (23) 8.8 (ms) Data Table
Neocortex basket cell somatosensory cortex layer 4 medial ganglionic eminence-derived parvalbumin-expressing interneurons membrane time constant (ms) 8.2 ± 0.6 (12) 8.2 (ms) Data Table
Neocortex Martinotti cell somatosensory cortex layer 4 medial ganglionic eminence-derived somatostatin-expressing interneurons rheobase (pA) 204.4 ± 23.5 (23) 204.4 (pA) Data Table
Neocortex basket cell somatosensory cortex layer 4 medial ganglionic eminence-derived parvalbumin-expressing interneurons rheobase (pA) 550.0 ± 69.9 (12) 550.0 (pA) Data Table
Neocortex Martinotti cell somatosensory cortex layer 4 medial ganglionic eminence-derived somatostatin-expressing interneurons resting membrane potential (mV) -65.3 ± 0.6 (23) -65.3 (mV) Data Table
Neocortex Martinotti cell somatosensory cortex layer 4 medial ganglionic eminence-derived somatostatin-expressing interneurons spike threshold (mV) -41.9 ± 0.8 (23) -41.9 (mV) Data Table
Neocortex basket cell somatosensory cortex layer 4 medial ganglionic eminence-derived parvalbumin-expressing interneurons spike threshold (mV) -42.4 ± 2.6 (12) -42.4 (mV) Data Table
Neocortex Martinotti cell somatosensory cortex layer 4 medial ganglionic eminence-derived somatostatin-expressing interneurons spike amplitude (mV) 64.9 ± 1.7 (23) 64.9 (mV) Data Table
Neocortex basket cell somatosensory cortex layer 4 medial ganglionic eminence-derived parvalbumin-expressing interneurons spike amplitude (mV) 60.7 ± 3.5 (12) 60.7 (mV) Data Table
Neocortex Martinotti cell somatosensory cortex layer 4 medial ganglionic eminence-derived somatostatin-expressing interneurons spike half-width (ms) 0.41 ± 0.01 (23) 0.41 (ms) Data Table
Neocortex basket cell somatosensory cortex layer 4 medial ganglionic eminence-derived parvalbumin-expressing interneurons spike half-width (ms) 0.23 ± 0.01 (12) 0.23 (ms) Data Table
Neocortex basket cell somatosensory cortex layer 4 medial ganglionic eminence-derived parvalbumin-expressing interneurons AHP amplitude (mV) 22.4 ± 0.8 (12) 22.4 (mV) Data Table
Neocortex basket cell somatosensory cortex layer 4 medial ganglionic eminence-derived parvalbumin-expressing interneurons resting membrane potential (mV) -70.8 ± 1.0 (12) -70.8 (mV) Data Table
Neocortex Martinotti cell somatosensory cortex layer 4 medial ganglionic eminence-derived somatostatin-expressing interneurons input resistance (MΩ) 118.8 ± 7.1 (23) 118.8 (MΩ) Data Table
Neocortex basket cell somatosensory cortex layer 4 medial ganglionic eminence-derived parvalbumin-expressing interneurons input resistance (MΩ) 71.3 ± 11.3 (12) 71.3 (MΩ) Data Table