Marker expression | Prototypic | Arkypallidal* | ||
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PV+ | PV-/FoxP2- | FoxP2+ | p | |
No. of neurons tested | 14 | 5 | 18 | - |
Input resistance (MΩ) | 450.2 ± 41.1 | 491.0 ± 63.8 | 556.2 ± 45.2 | 0.188 |
APth (mV) | -56.6 ± 1.8 | -49.9 ± 2.8 | -55.0 ± 1.8 | 0.208 |
APhw (ms) | 0.78 ± 0.07 | 0.73 ± 0.13 | 0.98 ± 0.16 | 0.394 |
AHP (mV) | -67.3 ± 2.2 | -66.7 ± 1.8** | -73.3 ± 1.8** | 0.044 |
AHP magnitude (APth - AHP) at autonomous firing rates | 10.6 ± 1.2** | 16.8 ± 2.6 | 18.2 ± 1.2** | 0.001 |
AHP magnitude at driven firing rate of ∼40 spk/s | 9.5 ± 1.1 | 12.2 ± 1.0 | 10.9 ± 1.0 | 0.363 |
Driven firing rate (spk/s) | 60.7 ± 7.6** | 51.4 ± 10.5 | 31.5 ± 2.9** | 0.001 |
Driven firing adaptation index | 0.64 ± 0.03 | 0.69 ± 0.11 | 0.78 ± 0.04 | 0.075 |
No. of neurons with rebound | 12/13 (92%) | 4/5 (80%) | 9/16 (56%) | - |
Rebound firing rate (spk/s) | 46.6 ± 13.5** | 21.7 ± 5.1 | 9.9 ± 3.2** | 0.012 |
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↵aSummary of intrinsic properties of prototypic and arkypallidal neurons recorded in a perforated-patch configuration. Values are given as mean ± SEM. APth, Action potential threshold; APhw, action potential half-width. Driven firing rate and adaptation were assessed with a 2 s current pulse of 100 pA. Mean rebound firing rate was assessed after a 500 ms current pulse of -150 pA; one PV+ prototypic neuron and two arkypallidal neurons could not be tested for rebound firing because of premature entry into a whole-cell configuration.
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↵*Reported for Kruskal-Wallis ANOVA on Ranks.
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↵**Neuron groups with statistically different values (p < 0.05; post hoc Dunn's test). When all prototypic neurons were pooled (n = 19) and their intrinsic properties were compared with those of arkypallidal neurons (Mann-Whitney tests), all parameters, except input resistance, APth, APhw, and AHP magnitude at ∼40 spk/s, were significantly different.