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Article: Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.

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Warmus BA; Sekar DR; McCutchen E; Schellenberg GD; Roberts RC; McMahon LL; Roberson ED
J. Neurosci., 2014


Table 1.

Intrinsic membrane properties and ability to fire action potentials were unchanged in the ventral striatum of hT-337M mice

Ntg hT-337M p
Input resistance (MΩ) 132.4 (4.7) 132.3 (6.5) 0.9876
Resting membrane potential (mV) -80.9 (0.7) -80.0 (0.6) 0.3797
AP threshold (mV) -27.4 (1.3) -27.2 (2.2) 0.9390
AP amplitude (mV) 67.8 (3.3) 66.0 (5.8) 0.7732
AP maximum rate of rise (mV/ms) 105.8 (7.6) 100.3 (10.7) 0.6800
AP half-width (ms) 1.24 (0.06) 1.25 (0.06) 0.8945
  • Whole-cell current-clamp recordings demonstrated that neurons in the ventral striatum of hT-337M mice have normal membrane excitability and are able to fire normal action potentials in response to current injections (n = 23 neurons in 9 Ntg mice, 11 neurons in 5 hT-337M mice; p value from two-tailed t test for each measurement) AP, Action potential.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens medium spiny neuron Ventral striatum neurons spike threshold (mV) -27.4 (9) -27.4 (mV) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons spike amplitude (mV) 67.8 (9) 67.8 (mV) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons spike max rise slope (mV/ms) 105.8 (9) 105.8 (mV/ms) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons input resistance (MΩ) 132.4 (9) 132.4 (MΩ) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons spike half-width (ms) 1.24 (9) 1.24 (ms) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons resting membrane potential (mV) -80.9 (9) -80.9 (mV) Data Table