Fast-spiking basket cells (n = 10) | Axo-axonic cells (n = 10) | Bistratified cells (n = 10) | O-LM cells (n = 10) | |
---|---|---|---|---|
Input resistance (MΩ) | 70.82 (60.94-88.64)a | 111.41 (70.96-137.1) | 117.26 (91.01-146.6) | 136.8 (86.59-199) |
Membrane time constant (ms) | 9.17 (7.06-11.83) | 10.58 (9.39-11.41) | 9.68 (8.71-14.32) | 18.14 (12.58-25.58) |
Membrane capacitance (pF) | 119 (84-141) | 89 (81-125) | 97 (79-103) | 144 (124-159) |
Relative sag amplitude | 0.191 (0.139-0.217) | 0.168 (0.133-0.176) | 0.092 (0.078-0.167)b | 0.500 (0.396-0.761) |
AP amplitude (mV) | 61.3 (53.9-63.3) | 65.3 (60.6-70.5) | 64.4 (59.8-77) | 72.8 (57.8-78) |
AP width at half-maximum (ms) | 0.4 (0.4-0.5) | 0.5 (0.4-0.5) | 0.4 (0.3-0.5) | 0.6 (0.5-0.8) |
AHP amplitude (mV) | 15.5 (12.8-18) | 14.8 (8.6-16.7)c | 17.9 (16-20.5) | 18.9 (16.6-22) |
Spike frequency (Hz) at small current stepsd | 51 (50-64) | 43 (41-83) | 65 (58-101) | 29 (18-49) |
Accommodation index at small current stepsd | 1.67 (1.33-1.93) | 2.02 (1.49-3) | 1.61 (1.5-1.9) | 1.66 (1.52-2.28) |
Spike frequency (Hz) at large current stepse | 61 (50-84) | 77 (56-114) | 66 (41-101) | 65 (51-78) |
Accommodation index at large current stepse | 1.76 (1.54-1.93) | 1.8 (1.16-3.28) | 1.94 (1.5-2.41) | 1.9 (1.55-2.82) |
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Data are presented as the median and the interquartile range in parentheses. Values indicated with bold differ significantly (p < 0.05) from all other cell types, while values in italics indicate significant differences from two other cell types. AP, Action potential; AHP, afterhyperpolarization.
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↵aFS BC versus AAC, p = 0.143; FS BC versus BIST, p = 0.015; FS BC versus O-LM, p = 0.002.
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↵bBIST versus AAC, p = 0.222; BIST versus BC, p = 0.022; BIST versus O-LM, p < 0.001.
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↵cAAC versus FS BC, p = 0.356; AAC versus BIST, p = 0.043; AAC versus O-LM, p = 0.015.
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↵dVoltage responses at which interneurons were capable to discharge continuously during the entire trace upon the smallest current injection (150-400 pA range for FS IN and 50-250 pA for O-LM cells) were compared.
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↵eVoltage responses at which interneurons fired with the highest frequency were compared.