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Article: Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex.

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Akgul G; Wollmuth LP
J. Neurosci., 2013


Table 2.

Passive and active membrane properties of juvenile and adult PV interneurons

Juvenile Adult
Firing pattern
    Delay first AP (ms) 462 ± 57 395 ± 79
    ISI average (ms) 25.9 ± 1.2 24.2 ± 1.4
    Frequency adaptation 1.03 ± 0.12 1.30 ± 0.09*
    Max ISI (ms) 109 ± 23 120 ± 40
    Min ISI (ms) 20.3 ± 1.3 18.4 ± 1.3
    Max/Min ISI 6.4 ± 1.7 7.6 ± 2.6
    CV frequency 0.20 ± 0.02 0.20 ± 0.03
    F/I slope (Hz/pA) 2.2 ± 0.3 1.2 ± 0.1***
Passive
    Vm (mV) -86 ± 1.4 -87 ± 1.2
    Rm (MΩ) 106 ± 10 159 ± 12***
    Rheobase (pA) 384 ± 46 228 ± 16**
AP shape
    AP threshold (mV) -46.3 ± 1.5 -49.6 ± 1.0*
    AP 10-90% rise (ms) 0.27 ± 0.01 0.25 ± 0.01
    AP half-width (ms) 0.54 ± 0.04 0.44 ± 0.03*
    AHP peak (mV) -24.7 ± 0.6 -23.8 ± 1.0
    AHP latency (ms) 2.2 ± 0.4 1.4 ± 0.2*
    AHP area (V/s) -298 ± 42 -213 ± 15*
    Number of interneurons 14 20

  • ↵Juvenile (P15-P17) or adult (P56-P65) PV interneurons are characterized by firing pattern, passive membrane properties, and AP shape (see Materials and Methods). Values shown as mean ± SEM. A t test was used to determine whether the value for juvenile was significantly different from that for adult (*p < 0.05, **p < 0.01, and ***p < 0.001). Note that the number of recorded interneurons is less than sampled for mRNA (19, juvenile; 21, adult) because not all interneurons sampled provided stable AP recordings.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron resting membrane potential (mV) -86.0 ± 1.4 (14) -86.0 (mV) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron resting membrane potential (mV) -87.0 ± 1.2 (20) -87.0 (mV) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron input resistance (MΩ) 106.0 ± 10.0 (14) 106.0 (MΩ) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron input resistance (MΩ) 159.0 ± 12.0 (20) 159.0 (MΩ) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron rheobase (pA) 384.0 ± 46.0 (14) 384.0 (pA) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron rheobase (pA) 228.0 ± 16.0 (20) 228.0 (pA) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron spike threshold (mV) -46.3 ± 1.5 (14) -46.3 (mV) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron spike threshold (mV) -49.6 ± 1.0 (20) -49.6 (mV) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron spike rise time (ms) 0.27 ± 0.01 (14) 0.27 (ms) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron spike rise time (ms) 0.25 ± 0.01 (20) 0.25 (ms) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron spike half-width (ms) 0.54 ± 0.04 (14) 0.54 (ms) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron spike half-width (ms) 0.44 ± 0.03 (20) 0.44 (ms) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron AHP amplitude (mV) -24.7 ± 0.6 (14) 24.7 (mV) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron AHP amplitude (mV) -23.8 ± 1.0 (20) 23.8 (mV) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron AHP duration (ms) 2.2 ± 0.4 (14) 2.2 (ms) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron AHP duration (ms) 1.4 ± 0.2 (20) 1.4 (ms) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron first spike latency (ms) 462.0 ± 57.0 (14) 462.0 (ms) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron first spike latency (ms) 395.0 ± 79.0 (20) 395.0 (ms) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron adaptation ratio (last/first ISI) 1.03 ± 0.12 (14) 1.03 (ratio) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron adaptation ratio (last/first ISI) 1.3 ± 0.09 (20) 1.3 (ratio) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron FI slope (Hz/pA) 2.2 ± 0.3 (14) 2200.0 (Hz/nA) Data Table
Neocortex basket cell Visual cortex layer 2/3 parvalbumin-expressing interneuron FI slope (Hz/pA) 1.2 ± 0.1 (20) 1200.0 (Hz/nA) Data Table