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Article: A distinct subtype of dopaminergic interneuron displays inverted structural plasticity at the axon initial segment.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Chand AN; Galliano E; Chesters RA; Grubb MS
J. Neurosci., 2015


Table 1.

Action potential parameters of OB dopaminergic neurons

Parameter Monophasic mean ± SEM (n) Biphasic mean ± SEM (n) Effect p value
10 mm NaCl 10 mm KCl 10 mm NaCl 10 mm KCl Cell type Treatment Interaction
Vthresh (mV) -24.7 ± 1.0 (23) -27.7 ± 1.1 (21) -34.2 ± 1.7 (17) -34.6 ± 1.5 (18) <0.0001*** 0.15 0.19
Onset rapidness (ms-1) 3.2 ± 0.3 (23) 3.2 ± 0.4 (19) 10.7 ± 1.7 (17) 9.9 ± 1.1 (18) <0.0001*** 0.52 0.55
Phase 1 peak amplitude (V/s) n/a n/a 46.1 ± 7.0 (17) 60.1 ± 10.1 (18) n/a 0.27 n/a
Peak rate-of-rise (V/s) 172 ± 21 (23) 158 ± 20 (21) 182 ± 19 (17) 205 ± 21 (18) 0.17 0.82 0.37
Peak voltage (mV) 34.5 ± 3.4 (23) 32.0 ± 3.4 (21) 38.0 ± 2.6 (17) 40.5 ± 2.2 (18) 0.14 0.77 0.32
Action potential width (ms) 1.06 ± 0.06 (23) 1.02 ± 0.06 (21) 1.09 ± 0.07 (17) 1.00 ± 0.06 (18) 0.81 0.24 0.87
Rheobase (pA/pF) 2.05 ± 0.97 (24) 1.37 ± 0.56 (26) 1.40 ± 0.19 (15) 1.52 ± 0.27 (15) 0.001*** 0.84 0.66
Afterhyperpolarization (mV) -53.4 ± 1.5 (24) -55.5 ± 1.2 (26) -54.1 ± 1.3 (15) -57.0 ± 1.4 (15) 0.63 0.12 0.53
Maximum frequency (Hz) 16.7 ± 1.8 (32) 19.0 ± 2.4 (31) 28.7 ± 4.3 (15) 35.5 ± 3.8 (16) <0.0001*** 0.12 0.43
Interstimulus interval CV 0.17 ± 0.03 (23) 0.14 ± 0.02 (26) 0.32 ± 0.06 (13) 0.26 ± 0.03 (15) <0.0001*** 0.60 0.40

  • Voltage threshold (Vthresh), peak rate-of-rise, peak voltage, and maximum frequency variables were normally distributed and analyzed with a standard two-way ANOVA. All other variables were non-normally distributed and analyzed with a two-way ANOVA on ranks, except phase 1 peak amplitude-measurable only in biphasic neurons-for which the result of a Mann-Whitney two-sample test is reported.

  • ↵***p ≤ 0.0001.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Olfactory Bulb dopaminergic monophasic interneuron spike threshold (mV) -24.7 ± 1.0 (23) -24.7 (mV) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron spike max rise slope (V/s) 172.0 ± 21.0 (23) 172.0 (mV/ms) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron spike max rise slope (V/s) 158.0 ± 20.0 (21) 158.0 (mV/ms) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron spike max rise slope (V/s) 182.0 ± 19.0 (17) 182.0 (mV/ms) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron spike max rise slope (V/s) 205.0 ± 21.0 (18) 205.0 (mV/ms) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron spike threshold (mV) -27.7 ± 1.1 (21) -27.7 (mV) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron spike amplitude (mV) 34.5 ± 3.4 (23) 34.5 (mV) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron spike amplitude (mV) 32.0 ± 3.4 (21) 32.0 (mV) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron spike amplitude (mV) 38.0 ± 2.6 (17) 38.0 (mV) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron spike amplitude (mV) 40.5 ± 2.2 (18) 40.5 (mV) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron spike threshold (mV) -34.2 ± 1.7 (17) -34.2 (mV) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron spike half-width (ms) 1.06 ± 0.06 (23) 1.06 (ms) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron spike half-width (ms) 1.02 ± 0.06 (21) 1.02 (ms) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron spike half-width (ms) 1.09 ± 0.07 (17) 1.09 (ms) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron spike half-width (ms) 1.0 ± 0.06 (18) 1.0 (ms) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron spike threshold (mV) -34.6 ± 1.5 (18) -34.6 (mV) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron AHP voltage (mV) -53.4 ± 1.5 (24) -53.4 (mV) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron AHP voltage (mV) -55.5 ± 1.2 (26) -55.5 (mV) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron AHP voltage (mV) -54.1 ± 1.3 (15) -54.1 (mV) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron AHP voltage (mV) -57.0 ± 1.4 (15) -57.0 (mV) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron maximum firing rate (Hz) 16.7 ± 1.8 (32) 16.7 (Hz) Data Table
Other Olfactory Bulb dopaminergic monophasic interneuron maximum firing rate (Hz) 19.0 ± 2.4 (31) 19.0 (Hz) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron maximum firing rate (Hz) 28.7 ± 4.3 (15) 28.7 (Hz) Data Table
Other Olfactory Bulb dopaminergic biphasic interneuron maximum firing rate (Hz) 35.5 ± 3.8 (16) 35.5 (Hz) Data Table