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Article: Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function.

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Rebello TJ; Yu Q; Goodfellow NM; Caffrey Cagliostro MK; Teissier A; Morelli E; Demireva EY; Chemiakine A; Rosoklija GB; Dwork AJ; Lambe EK; Gingrich JA; Ansorge MS
J. Neurosci., 2014


Table 5.

Intrinsic properties of pyramidal neurons in the IL and PL regions of adult PN-FLX and PN-VEH mice

Vm (mV) Spike amplitude (mV) Rin (MΩ) Cm (pF) Rheobase (pA)
IL layer II/III
    Saline (n = 13) -85.5 ± 2.8 87.3 ± 1.5 165.0 ± 25.9 86.5 ± 5.0 134 ± 26
    Fluoxetine (n = 19) -83.6 ± 1.8 84.9 ± 1.2 130.9 ± 13.2 91.6 ± 9.0 150 ± 16 (n = 17)
    p value 0.6 0.2 0.2 0.7 0.6
PL layer II/III
    Saline (n = 10) -86.6 ± 2.4 88.5 ± 1.1 77.9 ± 15.4 99.8 ± 7.5 255 ± 31
    Fluoxetine (n = 20) -88.9 ± 1.6 83.7 ± 1.4 115.7 ± 13.7 87.1 ± 4.9 173 ± 21 (n = 17)
    p value 0.4 0.04* 0.1 0.1 0.03*
  • Data are mean ± SEM. Vm, Resting membrane potential; spike amplitude in mV; Rin, input resistance; Cm, membrane capacitance. N values are indicated in the table.

  • *p < 0.05.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 infralimbic pyramidal cell resting membrane potential (mV) -85.5 ± 2.8 (13) -85.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 infralimbic pyramidal cell spike amplitude (mV) 87.3 ± 1.5 (13) 87.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 infralimbic pyramidal cell input resistance (MΩ) 165.0 ± 25.9 (13) 165.0 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 infralimbic pyramidal cell cell capacitance (pF) 86.5 ± 5.0 (13) 86.5 (pF) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 infralimbic pyramidal cell rheobase (pA) 134.0 ± 26.0 (13) 134.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 prelimbic pyramidal cell resting membrane potential (mV) -86.6 ± 2.4 (10) -86.6 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 prelimbic pyramidal cell spike amplitude (mV) 88.5 ± 1.1 (10) 88.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 prelimbic pyramidal cell input resistance (MΩ) 77.9 ± 15.4 (10) 77.9 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 prelimbic pyramidal cell cell capacitance (pF) 99.8 ± 7.5 (10) 99.8 (pF) Data Table
Neocortex pyramidal cell layer 2-3 Medial prefrontal cortex layer 2-3 prelimbic pyramidal cell rheobase (pA) 255.0 ± 31.0 (10) 255.0 (pA) Data Table