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Article: Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hargus NJ; Merrick EC; Nigam A; Kalmar CL; Baheti AR; Bertram EH; Patel MK
Neurobiol. Dis., 2011


RMP (mV)Ri (mΩ)Threshold (mV)Width (ms)Amplitude (mV)UpstrokefAHP (mV)DAP (mV)mAHP (mV)n
Control Non-stellate-61.5 ± 0.949.3 ± 3.0-41.9 ± 0.60.84 ± 0.0479.4 ± 2.4255.7 ± 137.9 ± 0.50.3 ± 0.111.9 ± 0.614
TLE Non-stellate-59.3 ± 1.066.8 ± 4.4‡-45.2 ± 0.9*0.85 ± 0.0486.6 ± 2.8302.8 ± 17‡9.9 ± 0.7‡0.7 ± 0.312.9 ± 1.013
Control stellate-60.2 ± 1.153.5 ± 3.1-42.9 ± 0.50.79 ± 0.0381.7 ± 2.1248.9 ± 116.1 ± 0.62.2 ± 0.310.9 ± 0.518
TLE stellate-59.8 ± 1.162.9 ± 5.4-46.9 ± 1.6‡0.81 ± 0.0395.5 ± 4.5$303.4 ± 22‡8.7 ± 0.6‡2.8 ± 0.310.2 ± 0.411

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Medial entorhinal cortex layer 2 non-stellate cell medium AHP amplitude (mV) 11.9 ± 0.6 (14) 11.9 (mV) Data Table
Other Medial entorhinal cortex layer 2 non-stellate cell resting membrane potential (mV) -61.5 ± 0.9 (14) -61.5 (mV) Data Table
Medial entorhinal cortex layer II stellate cell resting membrane potential (mV) -60.2 ± 1.1 (18) -60.2 (mV) Data Table
Medial entorhinal cortex layer II stellate cell input resistance (mΩ) 53.5 ± 3.1 (18) 53.5 (MΩ) Data Table
Medial entorhinal cortex layer II stellate cell spike threshold (mV) -42.9 ± 0.5 (18) -42.9 (mV) Data Table
Medial entorhinal cortex layer II stellate cell spike half-width (ms) 0.79 ± 0.03 (18) 0.79 (ms) Data Table
Medial entorhinal cortex layer II stellate cell spike amplitude (mV) 81.7 ± 2.1 (18) 81.7 (mV) Data Table
Medial entorhinal cortex layer II stellate cell spike max rise slope 248.9 ± 11.0 (18) 248.9 (mV/ms) Data Table
Other Medial entorhinal cortex layer 2 non-stellate cell input resistance (mΩ) 49.3 ± 3.0 (14) 49.3 (MΩ) Data Table
Medial entorhinal cortex layer II stellate cell fast AHP amplitude (mV) 6.1 ± 0.6 (18) 6.1 (mV) Data Table
Medial entorhinal cortex layer II stellate cell ADP amplitude (mV) 2.2 ± 0.3 (18) 2.2 (mV) Data Table
Medial entorhinal cortex layer II stellate cell medium AHP amplitude (mV) 10.9 ± 0.5 (18) 10.9 (mV) Data Table
Other Medial entorhinal cortex layer 2 non-stellate cell spike threshold (mV) -41.9 ± 0.6 (14) -41.9 (mV) Data Table
Other Medial entorhinal cortex layer 2 non-stellate cell spike half-width (ms) 0.84 ± 0.04 (14) 0.84 (ms) Data Table
Other Medial entorhinal cortex layer 2 non-stellate cell spike amplitude (mV) 79.4 ± 2.4 (14) 79.4 (mV) Data Table
Other Medial entorhinal cortex layer 2 non-stellate cell spike max rise slope 255.7 ± 13.0 (14) 255.7 (mV/ms) Data Table
Other Medial entorhinal cortex layer 2 non-stellate cell fast AHP amplitude (mV) 7.9 ± 0.5 (14) 7.9 (mV) Data Table
Other Medial entorhinal cortex layer 2 non-stellate cell ADP amplitude (mV) 0.3 ± 0.1 (14) 0.3 (mV) Data Table