Article: Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Nakajima M; Görlich A; Heintz N Cell, 2014
Male (n=13) | Female (n=22) | p-value | |
---|---|---|---|
Vrest (mV) | -73.74 ± 3.39 | -68.57 ± 2.38 | 0.210 |
Rin (MΩ) | 299.2 ± 21.64 | 294.4 ± 23.05 | 0.890 |
τm (ms) | 15.02 ± 1.96 | 11.15 ± 1.05 | 0.066 |
APThr (mV) | -51.47 ± 1.32 | -50.58 ± 2.04 | 0.758 |
Spike width (ms) | 0.495 ± 0.031 | 0.546 ± 0.044 | 0.428 |
SpikeAR | 0.52 ± 0.06 | 0.50 ± 0.03 | 0.689 |
No significant gender differences were observed in any general physiological parameters of OxtrCre neurons. Values shown are expressed as mean ± SEM.: To characterize neuronal membrane properties, the following parameters were measured: Vrest: resting membrane potential; recorded immediately after whole-cell configuration was established. Rin: input resistance; determined from the voltage change upon −50 pA current pulse at resting membrane potential. τm: membrane time constant; was determined at 63% of the maximal response to a −50 pA current pulse. Spike width: determined as spike width at the half maximum between action potential peak and threshold. SpikeAR: spike adaptation ratio; was defined as the ratio between the steady state spike frequency (last 3 spikes) and the initial spike frequency (first 3 spikes) of a 300 ms lasting, 200 pA current pulse. In spontaneous activity recordings, 100 nM Oxytocin (#1910, TOCRIS Bioscience, UK) was bath applied for 10 min, and the number of spontaneous action potentials counted. Wash-out experiments were done, 10 min after Oxytocin was removed from the bath. Gender differences were tested with student t test and response to oxytocin was analyzed by a student t test with Welch correction. |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | membrane time constant (ms) | 15.02 ± 1.96 (13) | 15.02 (ms) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | membrane time constant (ms) | 11.15 ± 1.05 (22) | 11.15 (ms) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | spike threshold (mV) | -51.47 ± 1.32 (13) | -51.47 (mV) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | spike threshold (mV) | -50.58 ± 2.04 (22) | -50.58 (mV) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | spike half-width (ms) | 0.495 ± 0.031 (13) | 0.495 (ms) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | spike half-width (ms) | 0.546 ± 0.044 (22) | 0.546 (ms) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | resting membrane potential (mV) | -73.74 ± 3.39 (13) | -73.74 (mV) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | adaptation ratio | 0.52 ± 0.06 (13) | 0.52 (ratio) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | adaptation ratio | 0.5 ± 0.03 (22) | 0.5 (ratio) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | resting membrane potential (mV) | -68.57 ± 2.38 (22) | -68.57 (mV) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | input resistance (MΩ) | 299.2 ± 21.64 (13) | 299.2 (MΩ) | Data Table |
Neocortex Martinotti cell | Medial prefrontal cortex regular spiking somatostatin-positive Oxtr-expressing interneurons | input resistance (MΩ) | 294.4 ± 23.05 (22) | 294.4 (MΩ) | Data Table |