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Article: Hippocampal "cholinergic interneurons" visualized with the choline acetyltransferase promoter: anatomical distribution, intrinsic membrane properties, neurochemical characteristics, and capacity for cholinergic modulation.

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Yi F; Catudio-Garrett E; Gábriel R; Wilhelm M; Erdelyi F; Szabo G; Deisseroth K; Lawrence J
Front Synaptic Neurosci, 2015


Properties of hippocampal ChAT-YFP neurons.

Property CA1 ChAT-YFP CA3 ChAT-YFP CA3 PC MS-DBB YFP
Rin (MΩ) 236.2 ± 13.8†§* 143.8 ± 12.9§ 125.3 ± 11.3 369.8 ± 60.0*
τm (ms) 25.3 ± 1.8 38.3 ± 3.2 30.3 ± 2.3 25.4 ± 3.2
Cm (pF) 111.6 ± 7.6†* 267.0 ± 16.9§ 243.2 ± 21.6 72.2 ± 4.8*
Vm (mV) -57.9 ± 3.3 -67.9 ± 2.5 -75.0 ± 1.4 -46.9 ± 5.5
AP half width (μs) 969.6 ± 47.8* 1021.7 ± 38.0* 725.8 ± 26.5 1081.0 ± 42.0*
Sag (SS/peak) 0.95 ± 0.01 0.99 ± 0.01 1.00 ± 0.02 0.98 ± 0.01
Spontaneous firing 5/11 1/12 0/7 5/6
AP frequency (at 100 pA) 10.5 ± 1.9 0 0 4.3 ± 1.1

Compared to CA3 SP ChAT-YFP cells; p < 0.05.

Compared to MSDBB ChAT-YFP cells; p < 0.05.

Compared to CA3 SP YFP-negative cells; p < 0.05.
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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other medial septum-diagonal band of Broca cholinergic interneuron membrane time constant (ms) 25.4 ± 3.2 25.4 (ms) Data Table
Hippocampus CA1 IS-I neuron hippocampus CA1 cholinergic interneuron cell capacitance (pF) 111.6 ± 7.6 111.6 (pF) Data Table
Hippocampus CA3 oriens interneuron hippocampus CA3 cholinergic interneuron cell capacitance (pF) 267.0 ± 16.9 267.0 (pF) Data Table
Hippocampus CA3 pyramidal cell cell capacitance (pF) 243.2 ± 21.6 243.2 (pF) Data Table
Other medial septum-diagonal band of Broca cholinergic interneuron cell capacitance (pF) 72.2 ± 4.8 72.2 (pF) Data Table
Hippocampus CA1 IS-I neuron hippocampus CA1 cholinergic interneuron resting membrane potential (mV) -57.9 ± 3.3 -57.9 (mV) Data Table
Hippocampus CA3 oriens interneuron hippocampus CA3 cholinergic interneuron resting membrane potential (mV) -67.9 ± 2.5 -67.9 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -75.0 ± 1.4 -75.0 (mV) Data Table
Hippocampus CA1 IS-I neuron hippocampus CA1 cholinergic interneuron input resistance (MΩ) 236.2 ± 13.8 236.2 (MΩ) Data Table
Other medial septum-diagonal band of Broca cholinergic interneuron resting membrane potential (mV) -46.9 ± 5.5 -46.9 (mV) Data Table
Hippocampus CA1 IS-I neuron hippocampus CA1 cholinergic interneuron spike half-width (μs) 969.6 ± 47.8 0.9696 (ms) Data Table
Hippocampus CA3 oriens interneuron hippocampus CA3 cholinergic interneuron spike half-width (μs) 1021.7 ± 38.0 1.0217 (ms) Data Table
Hippocampus CA3 pyramidal cell spike half-width (μs) 725.8 ± 26.5 0.7258 (ms) Data Table
Other medial septum-diagonal band of Broca cholinergic interneuron spike half-width (μs) 1081.0 ± 42.0 1.081 (ms) Data Table
Hippocampus CA1 IS-I neuron hippocampus CA1 cholinergic interneuron sag ratio 0.95 ± 0.01 0.95 (ratio) Data Table
Hippocampus CA3 oriens interneuron hippocampus CA3 cholinergic interneuron sag ratio 0.99 ± 0.01 0.99 (ratio) Data Table
Hippocampus CA3 pyramidal cell sag ratio 1.0 ± 0.02 1.0 (ratio) Data Table
Hippocampus CA3 oriens interneuron hippocampus CA3 cholinergic interneuron input resistance (MΩ) 143.8 ± 12.9 143.8 (MΩ) Data Table
Other medial septum-diagonal band of Broca cholinergic interneuron sag ratio 0.98 ± 0.01 0.98 (ratio) Data Table
Hippocampus CA1 IS-I neuron hippocampus CA1 cholinergic interneuron firing frequency 10.5 ± 1.9 10.5 (Hz) Data Table
Hippocampus CA3 pyramidal cell input resistance (MΩ) 125.3 ± 11.3 125.3 (MΩ) Data Table
Other medial septum-diagonal band of Broca cholinergic interneuron firing frequency 4.3 ± 1.1 4.3 (Hz) Data Table
Other medial septum-diagonal band of Broca cholinergic interneuron input resistance (MΩ) 369.8 ± 60.0 369.8 (MΩ) Data Table
Hippocampus CA1 IS-I neuron hippocampus CA1 cholinergic interneuron membrane time constant (ms) 25.3 ± 1.8 25.3 (ms) Data Table
Hippocampus CA3 oriens interneuron hippocampus CA3 cholinergic interneuron membrane time constant (ms) 38.3 ± 3.2 38.3 (ms) Data Table
Hippocampus CA3 pyramidal cell membrane time constant (ms) 30.3 ± 2.3 30.3 (ms) Data Table