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Article: Cellular mechanisms for response heterogeneity among L2/3 pyramidal cells in whisker somatosensory cortex.

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Elstrott J; Clancy KB; Jafri H; Akimenko I; Feldman DE
J. Neurophysiol., 2014


Table 1.

Physiology of low- and high-threshold pyramidal cells

PropertiesLow Threshold (35 cells)High Threshold (34 cells)P Value
Burst step, pA above rheobase274 ± 13173 ± 16<0.0001
Burst step, absolute pA528 ± 13.7436 ± 21<0.001
Spike threshold, mV-35.5 ± 0.5-37.1 ± 0.4<0.01
Spike threshold - Vrest, mV39.1 ± 0.736.2 ± 0.6<0.01
Vrest, mV-74.6 ± 0.5-73.3 ± 0.60.059
Rheobase, pA254 ± 11273 ± 14n.s.
Sag ratio (Ih) (26 and 30 cells), mV1.0 ± 0.11.3 ± 0.1n.s.
Cm, pF279 ± 16.8288 ± 27.7n.s.
mAHP magnitude, mV-5.4 ± 0.3-5.8 ± 0.3n.s.
Rinput, MΩ77.8 ± 3.273.5 ± 2.8n.s.
Age, days19 ± 0.320 ± 0.2n.s.
Recording depth, μm68.1 ± 2.171.6 ± 2.6n.s.
Distance below pia, μm320.9 ± 11.6 (34 cells)315.2 ± 13.2 (29 cells)n.s.
  • Values are means ± SE. Burst step, current injection required to evoke an initial spike doublet with <10-ms interspike interval; Vrest, resting potential; Cm, membrane capacitance; Rinput, input resistance; n.s., not significant.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 Low Threshold Pyramidal Cell spike threshold (mV) -35.5 ± 0.5 (35) -35.5 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 High Threshold Pyramidal Cell spike threshold (mV) -37.1 ± 0.4 (34) -37.1 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 Low Threshold Pyramidal Cell resting membrane potential (mV) -74.6 ± 0.5 (35) -74.6 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 High Threshold Pyramidal Cell resting membrane potential (mV) -73.3 ± 0.6 (34) -73.3 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 Low Threshold Pyramidal Cell rheobase (pA) 254.0 ± 11.0 (35) 254.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 High Threshold Pyramidal Cell rheobase (pA) 273.0 ± 14.0 (34) 273.0 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 Low Threshold Pyramidal Cell sag ratio 1.0 ± 0.1 (35) 1.0 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 High Threshold Pyramidal Cell sag ratio 1.3 ± 0.1 (34) 1.3 (ratio) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 Low Threshold Pyramidal Cell cell capacitance (pF) 279.0 ± 16.8 (35) 279.0 (pF) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 High Threshold Pyramidal Cell cell capacitance (pF) 288.0 ± 27.7 (34) 288.0 (pF) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 Low Threshold Pyramidal Cell medium AHP voltage (mV) -5.4 ± 0.3 (35) -- Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 High Threshold Pyramidal Cell medium AHP voltage (mV) -5.8 ± 0.3 (34) -- Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 Low Threshold Pyramidal Cell input resistance (MΩ) 77.8 ± 3.2 (35) 77.8 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Somatosensory Cortex Layer 2-3 High Threshold Pyramidal Cell input resistance (MΩ) 73.5 ± 2.8 (34) 73.5 (MΩ) Data Table