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Article: Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Dufour MA; Woodhouse A; Amendola J; Goaillard JM Elife, 2014
| Age | ISI avg (s) | CVISI (%) | Membrane Time Constant (ms) | Rin (MOhm) | Cm (pF) | Sag (mV) | Rebound (ms) | AP threshold (mV) | AP amplitude (mV) | AP half-width (ms) | AP Rise Slope (mV/ms) | AP decay slope (mV/ms) | AHP (mV) | Gain start (Hz/100pA) | Gain end (Hz/100pA) | SFA index |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P2-P3 | 1.06 +/- 0.84 (9) | 130.5 +/- 40.1 (9) | 200.3 +/- 8.0 (5) | 1642 +/- 420 (5) | 129 +/- 34 (5) | 28.2 +/- 4.0 (9) | 465 +/- 134 (6) | -43.9 +/- 3.3 (9) | 59.5 +/- 9.6 (9) | 2.38 +/- 0.62 (9) | 47.6 +/- 21.7 (9) | -19.6 +/- 5.2 (9) | 14.1 +/- 4.9 (9) | 32.1 +/- 5.9 (6) | 20 +/- 7.8 (6) | 1.76 +/- 0.53 (6) |
| P5 | 1.36 +/- 1.60 (15) | 57.6 +/- 22.6 (15) | 86.9 +/- 13.7 (11) | 642 +/- 163 (11) | 146 +/- 52 (11) | 29.4 +/- 5.7 (14) | 339 +/- 188 (12) | -40.3 +/- 4.5 (15) | 47.1 +/- 7.4 (15) | 2.99 +/- 0.95 (15) | 24.5 +/- 10.8 (15) | -16.9 +/- 4.6 (15) | 20.1 +/- 4.5 (15) | 17.7 +/- 5 (7) | 8.8 +/- 2.1 (7) | 2.07 +/- 0.71 (7) |
| P6 | 0.78 +/- 0.56 (18) | 51.5 +/- 43.0 (18) | 70.3 +/- 23.9 (18) | 612 +/- 170 (18) | 118 +/- 32 (18) | 30.2 +/- 7.2 (18) | 316 +/- 127 (18) | -43.1 +/- 4.3 (19) | 49.0 +/- 9.2 (19) | 2.99 +/- 0.71 (19) | 25.1 +/- 19.2 (19) | -18.0 +/- 6.6 (19) | 21.0 +/- 3.7 (19) | 22.7 +/- 6.5 (10) | 11.7 +/- 3.7 (10) | 1.97 +/- 0.27 (10) |
| P7 | 0.97 +/- 0.93 (36) | 38.4 +/- 28.0 (36) | 89.3 +/- 24.4 (25) | 650 +/- 174 (26) | 143 +/- 38 (25) | 31.2 +/- 5.2 (25) | 249 +/- 89 (19) | -39.8 +/- 4.0 (35) | 46.3 +/- 7.8 (35) | 2.92 +/- 0.64 (35) | 23.8 +/- 8.6 (35) | -17.6 +/- 4.1 (35) | 22.6 +/- 3.7 (35) | 17.5 +/- 4.7 (13) | 8.83 +/- 2.4 (13) | 2.08 +/- 0.71 (13) |
| P8-P9 | 1.67 +/- 1.95 (18) | 38.0 +/- 23.2 (18) | 90.9 +/- 38.4 (21) | 576 +/- 268 (21) | 200 +/- 141 (21) | 29.6 +/- 6.2 (17) | 401 +/- 212 (15) | -42.8 +/- 4.3 (20) | 54.4 +/- 7.4 (20) | 2.74 +/- 0.82 (20) | 32.8 +/- 14.8 (20) | -20.2 +/- 5.9 (20) | 20.9 +/- 4.2 (20) | 18.1 +/- 4.3 (13) | 10.4 +/- 3.3 (13) | 1.80 +/- 0.31 (13) |
| P10-P11 | 0.68 +/- 0.41 (12) | 21.1 +/- 8.6 (12) | 80.6 +/- 28.6 (10) | 327 +/- 210 (10) | 281 +/- 109 (10) | 33.3 +/- 4.2 (10) | 330 +/- 165 (10) | -41.7 +/- 4.2 (11) | 50.6 +/- 11.6 (11) | 2.51 +/- 0.83 (11) | 36.3 +/- 21.2 (11) | -21.4 +/- 7.5 (11) | 20.7 +/- 4.9 (11) | 11 +/- 4.5 (10) | 11.5 +/- 5.3 (10) | 1.01 +/- 0.30 (10) |
| P12-P13 | 1.04 +/- 0.67 (15) | 19.6 +/- 15.1 (15) | 87.9 +/- 32.7 (17) | 369 +/- 166 (17) | 297 +/- 226 (17) | 32.4 +/- 3.7 (16) | 378 +/- 341 (16) | -45.4 +/- 3.7 (18) | 62.1 +/- 6.3 (18) | 1.86 +/- 0.27 (18) | 54.2 +/- 14.5 (18) | -29.7 +/- 4.2 (18) | 23.0 +/- 6.0 (18) | 13.2 +/- 5 (15) | 11.6 +/- 4.5 (15) | 1.29 +/- 0.80 (15) |
| P14 | 0.64 +/- 0.48 (16) | 12.8 +/- 8.3 (16) | 92.3 +/- 44.0 (14) | 460 +/- 192 (14) | 205 +/- 68 (14) | 35.6 +/- 2.9 (10) | 489 +/- 448 (9) | -44.2 +/- 2.3 (16) | 61.0 +/- 7.1 (16) | 1.91 +/- 0.54 (16) | 54.9 +/- 18.4 (16) | -30.9 +/- 8.5 (16) | 24.1 +/- 5.5 (16) | 12.2 +/- 4 (10) | 9.8 +/- 2.6 (10) | 1.30 +/- 0.50 (10) |
| P15-P16 | 0.88 +/- 0.38 (22) | 13.3 +/- 6.6 (22) | 77.8 +/- 28.5 (19) | 325 +/- 117 (19) | 245 +/- 67 (19) | 27.9 +/- 6.5 (33) | 340 +/- 207 (30) | -44.4 +/- 3.4 (30) | 60.1 +/- 6.5 (30) | 1.63 +/- 0.49 (30) | 56.2 +/- 18.3 (30) | -39.7 +/- 11.5 (30) | 26.1 +/- 4.0 (30) | 9.28 +/- 3.2 (26) | 9.28 +/- 4.2 (26) | 1.11 +/- 0.44 (26) |
| P17 | 0.82 +/- 0.40 (16) | 9.9 +/- 5.6 (16) | 83.5 +/- 25.7 (20) | 323 +/- 109 (22) | 283 +/- 160 (20) | 28.1 +/- 7.4 (35) | 375 +/- 270 (26) | -44.6 +/- 3.5 (28) | 62.1 +/- 8.6 (28) | 1.61 +/- 0.37 (28) | 58.2 +/- 16.2 (28) | -38.8 +/- 8.8 (28) | 28.1 +/- 5.0 (28) | 7.13 +/- 2.1 (14) | 8.28 +/- 2.9 (14) | 0.92 +/- 0.31 (14) |
| P18 | 0.63 +/- 0.30 (18) | 7.6 +/- 4.0 (18) | 89.0 +/- 24.2 (18) | 340 +/- 118 (18) | 280 +/- 86 (18) | 29.5 +/- 4.2 (22) | 433 +/- 222 (20) | -41.6 +/- 3.0 (21) | 55.5 +/- 4.7 (21) | 1.45 +/- 0.21 (21) | 50.6 +/- 15.6 (21) | -41.1 +/- 7.3 (21) | 28.4 +/- 3.2 (21) | 6.97 +/- 2 (12) | 7.59 +/- 2.9 (12) | 0.99 +/- 0.35 (12) |
| P19 | 0.71 +/- 0.32 (24) | 9.6 +/- 6.1 (24) | 89.9 +/- 28.1 (30) | 352 +/- 103 (30) | 270 +/- 106 (30) | 28.6 +/- 6.2 (38) | 456 +/- 278 (32) | -44.2 +/- 4.1 (33) | 58.2 +/- 8.8 (33) | 1.55 +/- 0.38 (33) | 54.3 +/- 21.1 (33) | -41.4 +/- 11.4 (33) | 27.4 +/- 4.6 (33) | 8.32 +/- 2.6 (19) | 9.3 +/- 2.6 (19) | 0.93 +/- 0.31 (19) |
| P20 | 0.77 +/- 0.42 (21) | 9.3 +/- 4.8 (21) | 88.5 +/- 41.8 (22) | 375 +/- 116 (23) | 231 +/- 66 (22) | 28.5 +/- 8.3 (24) | 572 +/- 493 (22) | -44.3 +/- 4.4 (24) | 61.6 +/- 8.8 (24) | 1.47 +/- 0.31 (24) | 59.3 +/- 21.2 (24) | -42.6 +/- 8.8 (24) | 28.0 +/- 5.0 (24) | 8.15 +/- 2.4 (16) | 9.21 +/- 3 (16) | 0.95 +/- 0.33 (16) |
| P21-P23 | 0.72 +/- 0.32 (19) | 7.5 +/- 4.5 (19) | 93.1 +/- 48.2 (21) | 319 +/- 115 (23) | 293 +/- 128 (21) | 27.5 +/- 6.6 (23) | 388 +/- 254 (22) | -43.9 +/- 4.0 (24) | 62.6 +/- 8.2 (24) | 1.50 +/- 0.37 (24) | 61.5 +/- 21.0 (24) | -44.1 +/- 11.4 (24) | 29.1 +/- 4.3 (24) | 6.79 +/- 2.1 (24) | 7 +/- 1.8 (24) | 1.01 +/- 0.32 (24) |
| P28-P29 | 0.92 +/- 0.54 (12) | 12.1 +/- 4.7 (12) | 148.3 +/- 42.6 (10) | 472 +/- 88 (10) | 316 +/- 83 (10) | 34.1 +/- 4.5 (13) | 736 +/- 375 (10) | -42.8 +/- 3.0 (12) | 62.4 +/- 5.3 (12) | 1.49 +/- 0.29 (12) | 63.0 +/- 14.3 (12) | -43.2 +/- 8.7 (12) | 28.6 +/- 6.2 (12) | 6.99 +/- 2.3 (10) | 6.82 +/- 1.4 (10) | 1.07 +/- 0.43 (10) |
| Abbreviations: ISIavg, averaged interspike interval; CVISI, coefficient of variation of the interspike interval; τm, membrane time constant; Rin, input resistance; Cm, membrane capacitance; Rebound, rebound delay; AP, action potential; AHP, after hyperpolarization; SFA, spike frequency adaptation.: | ||||||||||||||||