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Article: Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole-cell recording from CA1 neurons.

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J. Neurophysiol., 2012


Table 4.

Drug effects on the intrinsic properties of CA1 neurons

Control (n = 45) 3 μM Dib (n = 9) 10 μM CP (n = 12) 30 μM CP (n = 11) 100 μM CP (n = 5) 3 μM Dib and 30 μM CP (n = 11)
RMP, mV −62.5 ± 3.0 −59.7 ± 3.0 −62.4 ± 3.2 −65.6 ± 3.1 −64.0 ± 2.6 −63.5 ± 3.7
fAHP, mV −3.4 ± 1.9 −2.7 ± 1.7 Absent* (11/12) Absent* Absent* Absent*
AP threshold, mV −47.5 ± 4.4 −46.0 ± 3.8 −47.7 ± 2.7 −49.1 ± 2.8 −47.0 ± 3.4 −38.8 ± 4.6
AP freq (0.1 nA), Hz 12.7 ± 9.5 12.3 ± 9.5 6.8 ± 4.4 * 6.0 ± 2.1* 1.2 ± 1.3 0.5 ± 0.8
AP freq (0.2 nA), Hz 24.3 ± 9.5 34.2 ± 16.4 13.2 ± 4.2 9.4 ± 2.5 1.6 ± 0.9 2.3 ± 1.8
AP freq (0.3 nA), Hz 31.5 ± 8.7 N/A 16.8 ± 5.1 11.4 ± 2.8 2.2 ± 1.1 2.9 ± 2.3
AP ampl, mV 89.6 ± 10.0 70 ± 21.5* 82.3 ± 14.4 74.9 ± 15.4* 62.5 ± 15.0 70.5 ± 10.2*
AP dur (½ ampl), ms 1.0 ± 0.1 1.0 ± 0.2 1.0 ± 0.1 1.4 ± 0.9* 2.0 ± 2.6 1.3 ± 0.2*
Rin, MΩ 47.4 ± 8.4 46.6 ± 1.7 45.8 ± 6.3 66.8 ± 17.2* 80.9 ± 16.9 57.5 ± 11.5*
  • Values are means ± SD.

  • * P < 0.05;

  • P < 0.01. CP, carbetapentane; RMP, resting membrane potential; fAHP, fast afterhyperpolarization; AP, action potential; freq, frequency; dur (½ ampl), AP duration at ½ of AP amplitude; Rin, input resistance; N/A, not applicable.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell spike amplitude (mV) 89.6 ± 10.0 (45) 89.6 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width 1.0 ± 0.1 (45) 1.0 (ms) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 47.4 ± 8.4 (45) 47.4 (MΩ) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -62.5 ± 3.0 (45) -62.5 (mV) Data Table
Hippocampus CA1 pyramidal cell fast AHP amplitude (mV) -3.4 ± 1.9 (45) 3.4 (mV) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -47.5 ± 4.4 (45) -47.5 (mV) Data Table