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Article: Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole-cell recording from CA1 neurons.

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J. Neurophysiol., 2012


Table 5.

Properties of the last AP in the train

Control (n = 25) 10 μM Dib (n = 9) 10 μM CP (n = 12) 30 μM CP (n = 11) 3 μM Dib and 30 μM CP (n = 11)
sAHP ampl, mV −5.8 ± 1.8 −15.8 ± 5.0 −11.2 ± 2.9* −10.6 ± 2.3 −17.3 ± 3.1
AP thresh, mV −41.2 ± 4.0 −28.3 ± 4.2 −31.1 ± 4.0 −34.3 ± 4.3 −32.4 ± 3.1
AP ampl, mV 69.6 ± 9.5 43.9 ± 12.0 50.1 ± 11.5 47.4 ± 7.4 51.21 ± 6.7
AP dur (½ ampl), ms 1.2 ± 0.2 2.0 ± 1.7 1.4 ± 0.3 2.0 ± 0.5* 1.6 ± 0.1*
  • Values are means ± SD.

  • * P < 0.05;

  • P < 0.01. sAHP, slow afterhyperpolarization; thresh, threshold.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell slow AHP amplitude (mV) -5.8 ± 1.8 5.8 (mV) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -41.2 ± 4.0 -41.2 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 69.6 ± 9.5 69.6 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width 1.2 ± 0.2 1.2 (ms) Data Table