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Article: Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Liu B; Eisenach JC
J. Neurophysiol., 2005



TABLE 4.Membrane properties of axotomized large-, medium-, or small-diameter neurons after PSNL
Treatment Size Category
Large
 Medium
 Small
Sham Saline Clonidine Sham Saline Clonidine Sham Saline Clonidine
Cell size, µm 54.6 ± 0.9 53.2 ± 1.1 55.1 ± 1.2 40.1 ± 1.4 39.6 ± 1.2 35.5 ± 1.1 26.8 ± 1.5 28.7 ± 1.6 28.0 ± 1.2
    n 36 27 13 27 28 10 27 26 12
Vm, mV –64.2 ± 0.6 –60.7 ± 1.2* –59.9 ± 1.6* –63.6 ± 1.2 –59.3 ± 1.0* –56.9 ± 2.1* –59.1 ± 2.6 –58.3 ± 1.3 –56.8 ± 2.1
    n 36 27 13 27 28 10 27 26 12
Voltage threshold, mV –34.7 ± 1.4 –40.9 ± 1.4* –42.0 ± 2.5* –35.0 ± 2.1 –44.5 ± 1.3* –41.0 ± 1.8* –24.6 ± 1.6 –35.2 ± 1.6 –29.8 ± 2.4
    n 36 27 13 27 28 10 27 26 12
AP hight, mV 63.3 ± 1.5 65.2 ± 1.4 61.5 ± 4.2 64.6 ± 1.9 62.5 ± 1.6 65.6 ± 3.5 64.1 ± 2.0 62.2 ± 1.8 62.0 ± 3.0
    n 36 27 13 27 28 10 27 26 12
rheobase, nA 1.6 ± 0.1 0.8 ± 0.1* 0.9 ± 0.2* 1.4 ± 0.2 0.5 ± 0.1* 0.7 ± 0.1* 1.2 ± 0.1 0.5 ± 0.1* 0.5 ± 0.1*
    n 36 27 13 27 28 10 27 26 12
AP-D, ms 0.9 ± 0.1 2.2 ± 0.1* 2.0 ± 0.1* 1.5 ± 0.1 2.8 ± 0.2* 3.1 ± 0.4* 3.7 ± 0.3 4.4 ± 0.3 4.5 ± 0.3
    n 36 27 13 27 28 10 27 26 12
AHP, mV 11.6 ± 0.6 8.2 ± 0.6* 8.8 ± 1.0* 11.3 ± 0.7 9.4 ± 0.7 11.2 ± 1.9 11.0 ± 1.0 8.9 ± 1.1 13.0 ± 1.7
    n 35 22 13 26 26 10 27 21 12
AHP-D, ms 2.8 ± 0.2 3.5 ± 0.3 2.7 ± 0.2 3.4 ± 0.4 3.9 ± 0.4 4.7 ± 0.5 5.3 ± 0.4 6.6 ± 0.6 7.6 ± 0.7*
    n 35 22 13 26 26 10 27 21 12
Rin, Mohm 15.2 ± 1.2 21.5 ± 2.1* 17.0 ± 1.9 27.4 ± 3.3 25.2 ± 2.4 32.0 ± 8.0 59.0 ± 7.1 60.2 ± 8.7 53.2 ± 6.4
    n 35 27 13 27 28 10 27 26 12
aV/aT r., mV/ms 326.7 ± 14.6 205.4 ± 13.1* 218.0 ± 27.0* 220.2 ± 12.9 189.5 ± 10.2 175.7 ± 16.8* 136.3 ± 10.3 135.6 ± 12.5 135.0 ± 16.0
    n 36 27 13 24 25 10 27 26 12
aV/aT f., mV/ms –154.2 ± 14.1 –69.6 ± 4.5* –95.9 ± 11.8* –105.3 ± 6.7 –51.8 ± 3.3* –69.2 ± 8.4* –46.0 ± 2.4 –35.4 ± 2.6* –41.8 ± 3.3
    n 36 27 13 26 28 10 27 25 12
Values, expressed as means ± SE, were obtained from both L4 and L5 dorsal root ganglion axotomized neurons; n = recorded number of neurons.

* P < 0.05, PSNL group versus Sham group.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell dorsal root ganglion medium cell rheobase (nA) 0.9 ± 0.2 -- Data Table
Dorsal root ganglion cell dorsal root ganglion small cell rheobase (nA) 0.7 ± 0.1 -- Data Table
Dorsal root ganglion cell dorsal root ganglion medium cell AHP duration (ms) 2.7 ± 0.2 -- Data Table
Dorsal root ganglion cell dorsal root ganglion small cell AHP duration (ms) 4.7 ± 0.5 -- Data Table
Dorsal root ganglion cell dorsal root ganglion medium cell input resistance (Mohm) 17.0 ± 1.9 -- Data Table
Dorsal root ganglion cell dorsal root ganglion small cell input resistance (Mohm) 32.0 ± 8.0 -- Data Table
Dorsal root ganglion cell dorsal root ganglion medium cell resting membrane potential (mV) -59.9 ± 1.6 -- Data Table
Dorsal root ganglion cell dorsal root ganglion small cell resting membrane potential (mV) -56.9 ± 2.1 -- Data Table
Dorsal root ganglion cell dorsal root ganglion medium cell spike threshold (mV) -42.0 ± 2.5 -- Data Table
Dorsal root ganglion cell dorsal root ganglion small cell spike threshold (mV) -41.0 ± 1.8 -- Data Table
Dorsal root ganglion cell dorsal root ganglion medium cell spike amplitude (mV) 61.5 ± 4.2 -- Data Table
Dorsal root ganglion cell dorsal root ganglion small cell spike amplitude (mV) 65.6 ± 3.5 -- Data Table