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Article: Does a unique type of CA3 pyramidal cell in primates bypass the dentate gate?

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Buckmaster PS
J. Neurophysiol., 2005



TABLE 1.Action potential threshold for stimulation of the dentate gyrus molecular layer, intrinsic physiological properties, and maximum inhibitory postsynaptic potential amplitude of three types of morphologically defined proximal CA3 pyramidal cells in macaque monkeys


Classical CA3 Pyramidal Cell Nonapical CA3 Pyramidal Cell Dentate CA3 Pyramidal Cell

Action potential threshold for molecular layer stimulation (xT*) 1.22 ± 0.36 1.14 ± 0.50 1.14 ± 0.23
Cells with action potential threshold < 1 xT (%) 17 39 29
Resting membrane potential (mV) –67 ± 4 –66 ± 5 –64 ± 4
Input resistance (MΩ) 105 ± 39 109 ± 27 99 ± 46
Action potential voltage threshold (mV) –50 ± 3 –48 ± 4 –48 ± 4
Action potential amplitude (mV) 71 ± 8 71 ± 9 72 ± 5
Action potential base width (ms) 1.58 ± 0.15 1.51 ± 0.27 1.57 ± 0.24
Maximum IPSP amplitude (mV) 6 ± 3 10 ± 4 8 ± 1
Number of cells 12 23 7

Values represent means ± SD.

* T, threshold stimulus intensity for evoking the dentate gyrus field potential population spike. There were no significant differences in the evoked action potential threshold or intrinsic electrophysiological properties among the three types of pyramidal cells (ANOVA or χ2).

The maximum inhibitory postsynaptic potential (IPSP) amplitude of classical CA3 pyramidal cells was significantly less than that of nonapical CA3 pyramidal cells (P = 0.036, post hoc Bonferroni t-test).


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA3 pyramidal cell resting membrane potential (mV) -67.0 ± 4.0 (12) -67.0 (mV) Data Table
Hippocampus CA3 pyramidal cell Nonapical CA3 pyramidal cell resting membrane potential (mV) -66.0 ± 5.0 (23) -66.0 (mV) Data Table
Hippocampus CA3 pyramidal cell Dentate CA3 pyramidal cell resting membrane potential (mV) -64.0 ± 4.0 (7) -64.0 (mV) Data Table
Hippocampus CA3 pyramidal cell input resistance (MΩ) 105.0 ± 39.0 (12) 105.0 (MΩ) Data Table
Hippocampus CA3 pyramidal cell Nonapical CA3 pyramidal cell input resistance (MΩ) 109.0 ± 27.0 (23) 109.0 (MΩ) Data Table
Hippocampus CA3 pyramidal cell Dentate CA3 pyramidal cell input resistance (MΩ) 99.0 ± 46.0 (7) 99.0 (MΩ) Data Table
Hippocampus CA3 pyramidal cell spike threshold (mV) -50.0 ± 3.0 (12) -50.0 (mV) Data Table
Hippocampus CA3 pyramidal cell Nonapical CA3 pyramidal cell spike threshold (mV) -48.0 ± 4.0 (23) -48.0 (mV) Data Table
Hippocampus CA3 pyramidal cell Dentate CA3 pyramidal cell spike threshold (mV) -48.0 ± 4.0 (7) -48.0 (mV) Data Table
Hippocampus CA3 pyramidal cell spike amplitude from resting (mV) 71.0 ± 8.0 (12) 71.0 (mV) Data Table
Hippocampus CA3 pyramidal cell Nonapical CA3 pyramidal cell spike amplitude from resting (mV) 71.0 ± 9.0 (23) 71.0 (mV) Data Table
Hippocampus CA3 pyramidal cell Dentate CA3 pyramidal cell spike amplitude from resting (mV) 72.0 ± 5.0 (7) 72.0 (mV) Data Table
Hippocampus CA3 pyramidal cell spike width (ms) 1.58 ± 0.15 (12) 1.58 (ms) Data Table
Hippocampus CA3 pyramidal cell Nonapical CA3 pyramidal cell spike width (ms) 1.51 ± 0.27 (23) 1.51 (ms) Data Table
Hippocampus CA3 pyramidal cell Dentate CA3 pyramidal cell spike width (ms) 1.57 ± 0.24 (7) 1.57 (ms) Data Table