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Article: Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels.

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Kasten MR; Rudy B; Anderson MP
J. Physiol. (Lond.), 2007


Table 1. Membrane and action potential properties

Ctrl (n = 82) Kv3.2 KO (n = 16) TEA (n = 8) d15 (n = 6) DTX 100 nm (n = 7) MTX 10 nm (n = 5) Ba2+ 100 μm (n = 12) Ba2+ 10 μm (n = 6) Glib (n = 9) Diaz (n = 8) XE 991 10 μm (n = 7)
Vm (mV) −76.4 ± −76.8 ± −76.3 ± − 69.8 ± −72.7 ± −73.5 ± −64.8 ± −74.8 ± −78.0 ± −77.6 ± −75.3 ±
0.3 0.7 1.1 1.2* 2.0 2.4 1.4** 1.0 0.9 0.7 0.7
Rin (MΩ) 136.4 ± 102.9 ± 148.2 ± 383.3 ± 153.6 ± 102.7 ± 274.8 ± 128.0 ± 145.6 ± 94.1 ± 156.4 ±
(−20 pA) 6.0 5.8** 15.5 52.3* 27.0 6.8* 48.7* 9.0 30.7 7.6** 9.1
Rin (MΩ) 157.0 ± 117.1 ± 162.2 ± 645.0 ± 231.6 ± 133.7 ± 322.3 ± 127.3 ± 164.9 ± 104.7 ± 179.6 ±
(+20 pA) 8.0 7.4** 16.0 49.6** 65.1 17.1* 81.2 10.2 39.9 8.2** 29.6
Rin (MΩ) 98.4 ± 83.6 ± 102.9 ± 281.3 ± 111.9 ± 81.0 ± 166.0 ± 93.5 ± 100.9 ± 81.8 ± 110.7 ±
(−100 pA) 3.1 2.8** 8.4 16.7** 14.0 3.4 20.6* 7.1 11.5 7.8 3.9*
Vth (mV) −45.8 ± −45.8 ± −45.0 ± −36.8 ± −51.0 ± −46.6 ± −47.8 ± −52.5 ± −48.4 ± −43.4 ± −45.7 ±
0.5 1.2 1.4* 1.3** 0.8** 2.4 1.3 1.5* 1.5 1.6 1.5
AP up-slope 336.2 ± 314.1 ± 350.0 ± 147.4 ± 414.1 ± 257.3 ± 339.5 ± 393.5 ± 331.6 ± 380.2 ± 375.2 ±
(V s−1) 3.7 14.5 25.9 28.3** 19.4* 32.6* 16.7 44.4 22.3 30.9 31.6
AP down-slope 168.9 ± 137.7 ± 94.6 ± 44.1 ± 223.2 ± 179.4 ± 135.5 ± 189.5 ± 145.6 ± 165.7 ± 172.4 ±
(V s−1) 3.7 4.4** 7.6** 6.3** 17.0* 19.1* 6.9** 9.7 7.3* 9.4 7.3
AP half- 415.3 ± 447.2 ± 556.9 ± 987.0 ± 384.1 ± 439.7 ± 453.5 ± 381.6 ± 478.8 ± 391.9 ± 389.6 ±
width (μs) 7.2 13.0* 28.6** 104.8* 16.2 29.0 13.7* 17.9 20.1* 11.7 9.2*
fAHP (mV) 16.7 ± 13.1 ± 6.5 ± 10.4 ± 14.9 ± 14.4 ± 10.2 ± 13.3 ± 15.7 ± 18.8 ± 17.9 ±
0.3 0.8 1.6** 1.2* 0.5 1.9 1.0** 1.5 1.1 1.5 0.6
mAHP (mV) 13.1 ± 13.7 ± 11.5 ± 17.7 ± 9.1 ± 8.4 ± 10.8 ± 10.1 ± 14.2 ± 14.0 ± 14.1 ±
0.3 1.0 0.9* 1.4* 0.4** 1.1 0.6* 0.8* 1.0 1.0 0.7
Ctrl (n = 30) Pax (n = 7) Apamin (n = 7) Ni (n = 11) Nife (n = 8) CTX MVIIC (n = 6) CTX GVIA (n = 12) AGA IVA (n = 9) GKO (n = 12)
*P < 0.05, **P < 0.001, mean ± s.e.m., pipette: 100 μm EGTA (above) and 1 mm EGTA (below).
Vm (mV) −74.8 ± −74.7 ± −74.4 ± −73.6 ± −75.0 ± −74.0 ± −75.6 ± −75.4 ± −77.6 ±
0.3 3.2 0.3 0.7 1.3 1.9 0.6 0.6 0.6**
Rin (MΩ) 118.8 ± 121.7 ± 136.9 ± 120.9 ± 120.9 ± 104.2 ± 128.3 ± 98.4 ± 107.8 ±
(−20 pA) 8.3 10.2 0.3 10.0 7.1 14.6 12.4 7.0 8.4
Rin (MΩ) 126.3 ± 127.5 ± 137.1 ± 138.2 ± 125.3 ± 102.1 ± 107.7 ± 95.3 ± 135.8 ±
(+20 pA) 8.5 11.6 0.3 14.4 12.9 13.0 10.4 11.1 10.4
Rin (MΩ) 90.0 ± 100.0 ± 102.8 ± 97.3 ± 95.6 ± 71.0 ± 91.9 ± 72.1 ± 80.7 ±
(−100 pA) 5.1 2.5 0.3 9.2 9.4 10.7 6.1 7.0 6.6
Vth (mV) −46.7 ± −49.4 ± −45.7 ± −47.5 ± −48.8 ± −49.6 ± −46.9 ± −46.2 ± −45.9 ±
0.8 1.2 0.3 1.1 1.8 2.7 1.0 1.1 1.0
AP up-slope 310.5 ± 334.8 ± 304.0 ± 277.7 ± 316.6 ± 307.2 ± 394.0 ± 377.2 ± 367.5 ±
(V s−1) 13.9 25.8 0.3 25.2 19.7 43.1 25.8** 17.7* 40.3
AP down-slope 159.2 ± 129.0 ± 148.4 ± 158.5 ± 157.0 ± 161.9 ± 204.8 ± 173.9 ± 191.1 ±
(V s−1) 3.9 9.6* 0.3 7.9 6.9 14.0 12.6** 5.6* 13.9*
AP half- 439.3 ± 485.0 ± 466.4 ± 444.1 ± 450.2 ± 424.4 ± 340.7 ± 387.2 ± 375.9 ±
width (μs) 10.5 20.8 0.3 18.3 8.1 21.6 11.3** 13.0* 29.8
fAHP (mV) 16.2 ± 11.8 ± 17.7 ± 13.5 ± 14.9 ± 13.1 ± 16.6 ± 16.7 ± 19.9 ±
0.6 0.7* 0.3 1.1** 0.8 0.8* 0.9 0.7 1.2*
mAHP (mV) 12.7 ± 8.5 ± 12.2 ± 9.8 ± 13.4 ± 7.1 ± 10.4 ± 12.5 ± 13.9 ±
0.5 1.4* 0.3* 1.1** 1.3 1.7* 0.8* 0.6 0.7

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Thalamus relay cell Lateral dorsal thalamic relay nucleus spike max rise slope 336.2 (82) 336.2 (mV/ms) Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus spike max decay slope 168.9 (82) 168.9 (mV/ms) Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus spike half-width 415.3 (82) -- Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus fast AHP amplitude (mV) 16.7 (82) 16.7 (mV) Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus resting membrane potential (mV) -76.4 (82) -76.4 (mV) Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus medium AHP amplitude (mV) 13.1 (82) 13.1 (mV) Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus input resistance (MΩ) 136.4 (82) 136.4 (MΩ) Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus input resistance (MΩ) 157.0 (82) 157.0 (MΩ) Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus input resistance (MΩ) 98.4 (82) 98.4 (MΩ) Data Table
Thalamus relay cell Lateral dorsal thalamic relay nucleus spike threshold (mV) -45.8 (82) -45.8 (mV) Data Table