TABLE 1.Statistical comparison PTZ vs. control
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| Pyramidal Cells |
Interneurons |
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| Control |
Postseizure |
Control |
Postseizure |
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| Input resistance, MΩ | 37 ± 2 (25) | 38 ± 1 (93) | 57 ± 16 (6) | 46.6 ± 5 (23) | ||
| Resting membrane potential, mV | -63 ± 2 (25) | -64 ± 1 (93) | -63 ± 4 (6) | -68 ± 2 (23)* | ||
| Action potential duration, ms | 1.3 ± 0.02 (20) | 1.4 ± 0.02 (20) | 1.05 ± 0.2 (6) | 1.3 ± 0.1 (23) | ||
| AHP amplitude, mV | 5.4 ± 1 (25) | 4.8 ± 1.5 (20) | 10 ± 2 (6) | 14.1 ± 1 (23)** | ||
| AHP duration, ms | 6.2 ± 0.2 (25) | 6.4 ± 0.3 (20) | 33 ± 14 (6) | 35 ± 7 (23) | ||
| DG-EPSP amplitude, mV | 4.6 ± 0.4 (30) | 6.3 ± 0.2 (93)** | 4.2 ± 0.3 (6) | 5.4 ± 0.5 (16)** | ||
| DG-EPSP onset latency, ms | 4.5 ± 0.2 (30) | 4.4 ± 0.8 (93) | 4.3 ± 0.2 (6) | 4.6 ± 0.1 (16) | ||
| DG-EPSP time to peak, ms | 14 ± 0.2 (30) | 12 ± 0.4 (93)** | 7.1 ± 0.2 (6) | 11 ± 0.9 (16)** | ||
| DG-EPSP rise time, 10-90%; ms | 2.5 ± 0.2 (30) | 3.9 ± 0.3 (93)** | 1.8 ± 0.3 (6) | 3.2 ± 0.3 (16)** | ||
| DG-IPSP amplitude, mV | — | 3.4 ± 0.4 (25) | — | 1.7 ± 0.4 (10) | ||
| DG-IPSP onset latency, ms | — | 4.3 ± 0.3 (25) | — | 4.8 ± 0.06 (10) | ||
| DG-IPSP time to peak, ms | — | 19 ± 0.1 (25) | — | 13.5 ± 0.6 (10) | ||
| DG-IPSP rise time, 10-90%; ms | — | 14 ± 1.2 (25) | — | 7.5 ± 0.8 (10) | ||
| DG-IPSP reversal potential | — | -67 ± 0.7 (25) | — | -69.4 ± 0.6 (10) | ||
| DG-EPSPm onset latency, ms | — | 6.1 ± 0.2 (93) | — | 6.8 ± 0.4 (5) | ||
| DG-EPSPm amplitude, mV | — | 1.8 ± 0.1 (93) | — | 0.8 ± 0.1 (5) | ||
| DG-EPSPm duration, ms | — | 137 ± 5 (93) | — | 201 ± 7 (5) | ||
| DG-EPSPm rise time, 10-90%; ms | — | 20.5 ± 0.1 (93) | — | 38.6 ± 5 (5) | ||
| DG-IPSP amplitude, mV; with ACh-antag. | — | 6.8 ± 0.8 (9) | — | 1.8 ± 0.1 (3) | ||
| DG-IPSP time to peak, ms; with ACh-antag. | — | 11.2 ± 0.2 (9) | — | 13 ± 0.5 (3) | ||
| DG-IPSP rise time, 10-90%; ms; with ACh-antag. | — | 7 ± 0.1 (9) | — | 6.4 ± 0.6 (3) | ||
| DG-IPSP reversal potential, with ACh-antag. | — | -72.4 ± 0.6 (9) | — | -71.2 ± 0.8 (3) | ||
| A/C-EPSPm onset latency, ms | 7.3 ± 0.1 (3) | 4.6 ± 0.1 (15) | — | — | ||
| A/C-EPSPm amplitude, mV | 1.6 ± 0.5 (3) | 1.9 ± 0.1 (15) | — | — | ||
| A/C-EPSPm duration, ms | 98.3 ± 2.8 (3) | 113.9 ± 2.4 (15) | — | — | ||
| A/C-EPSPm rise time, 10-90%; ms |
17.9 ± 2.4 (3) |
18.4 ± 0.1 (15) |
— |
— |
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Student's t-test; values are means ± SE; n values are in parentheses. AHP, afterhyperpolarization; DG, dentate gyrus; EPSP and IPSP, excitatory and inhibitory postsynaptic potential; A/C, associational/commissural. *P < 0.05; **P < 0.01.