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Article: Activity-dependent depression of the spike after-depolarization generates long-lasting intrinsic plasticity in hippocampal CA3 pyramidal neurons.

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Brown JT; Randall AD
J. Physiol. (Lond.), 2009


Table 1. Electrophysiological properties of CA3 neurons

*Calculated from the voltage deflection in response to a −100 pA current injection. †Measured from first spike in response to a +300 pA depolarizing current injection. ‡ADP measured following a single action potential elicited by a 2 ms, +2 nA depolarizing current injection.
Resting membrane potential −75 ± 1 mV 
Membrane time constant (*) 48.4 ± 1.3 ms
Input resistance (*) 167 ± 4 MΩ
Extrapolated input resistance (*) 204 ± 5 MΩ
% sag (*) 17.3 ± 1.1% 
Mean number of action potentials (current injection: 300/200 pA) 10.4 ± 0.5/8.0 ± 0.5
Action potential threshold† −58.1 ± 0.3 mV 
Action potential peak†  29.0 ± 0.5 mV
Action potential width at 0 mV†  0.57 ± 0.01 ms
ADP amplitude‡  15.2 ± 0.5 mV
n 95

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA3 pyramidal cell sag ratio (*) 17.3 ± 1.1 (95) -- Data Table
Hippocampus CA3 pyramidal cell spike threshold -58.1 ± 0.3 (95) -58.1 (mV) Data Table
Hippocampus CA3 pyramidal cell spike peak 29.0 ± 0.5 (95) 29.0 (mV) Data Table
Hippocampus CA3 pyramidal cell spike half-width (at) 0.57 ± 0.01 (95) -- Data Table
Hippocampus CA3 pyramidal cell ADP amplitude 15.2 ± 0.5 (95) 15.2 (mV) Data Table
Hippocampus CA3 pyramidal cell resting membrane potential -75.0 ± 1.0 (95) -75.0 (mV) Data Table
Hippocampus CA3 pyramidal cell membrane time constant (*) 48.4 ± 1.3 (95) -- Data Table
Hippocampus CA3 pyramidal cell input resistance (*) 167.0 ± 4.0 (95) -- Data Table
Hippocampus CA3 pyramidal cell input resistance (*) 204.0 ± 5.0 (95) -- Data Table