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Article: Cell-type-specific GABA responses and chloride homeostasis in the cortex and amygdala.

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Martina M; Royer S; Paré D
J. Neurophysiol., 2001


Table 1.

Physiological properties and GABAA reversals of RS and FS neurons

Cell Type Physiological Properties GABAAReversal
Resting Vm, mV Rin, MΩ τ, ms Spike amplitude, mV Spike duration at half-amplitude, ms Endogenous, 1-a mV Exogenous, 1-b mV
Regular spiking
 LA −82.2  ±  1.0 198.5  ±  18.5 32.6  ±  3.2 80.7  ±  1.7 1.24  ±  0.08 −74.1  ±  1.9 −72.4  ±  1.1
  n 21 21 21 21 21 3 18
 PRH −81.0  ±  1.4 183.0  ±  12.3 32.1  ±  2.4 85.3  ±  2.1 1.15  ±  0.04 −70.0  ±  1.0 −72.3  ±  0.8
  n 23 23 23 23 23 6 17
 Parietal −80.6  ±  1.0 235.2  ±  19.5 29.9  ±  1.2 82.4  ±  1.3 1.10  ±  0.04 −74.6  ±  1.8 −73.0  ±  0.9
  n 18 18 18 18 18 3 15
 Pooled −81.3  ±  0.6 203.7  ±  9.8 31.3  ±  1.5 82.9  ±  1.1 1.16  ±  0.03 −72.4  ±  1.0 −72.8  ±  0.6
  n 62 62 62 62 62 12 50
Fast spiking
 LA −66.4  ±  1.6 427.1  ±  45.7 21.4  ±  2.6 86.2  ±  3.1 0.56  ±  0.04 −54.8  ±  1.1 −57.5  ±  1.2
  n 13 13 13 13 13 3 6
 PRH −68.0  ±  1.2 352.8  ±  43.7 17.1  ±  2.1 81.3  ±  4.6 0.47  ±  0.05 −52.7  ±  3.3 −57.2  ±  0.6
  n 21 21 21 21 21 4 13
 Parietal −69.2  ±  1.6 395.1  ±  43.6 19.2  ±  3.5 87.4  ±  1.8 0.49  ±  0.04 −55.0  ±  1.3 −57.8  ±  2.5
  n 7 7 7 7 7 3 3
 Pooled −67.7  ±  0.8 384.3  ±  27.2 19.1  ±  1.5 84.0  ±  2.6 0.50  ±  0.03 −54.1  ±  1.3 −57.4  ±  0.6
  n 41 41 41 41 41 10 22
  • Values are means ± SE.

  • F1-a  Electrically evoked inhibitory postsynaptic potential in the presence of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) andd(−)-2-amino-5-phosphonopentanoic acid (AP-5).

  • F1-b  For regular-spiking (RS) cells, responses to isoguvacine. For fast-spiking (FS) cells, results obtained with isoguvacine and GABA were pooled.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus regular-spiking spiny, multi-polar pyramidal cell resting membrane potential (mV) -82.2 ± 1.0 (21) -82.2 (mV) Data Table
Other Perirhinal cortex fast-spiking aspiny, varicose dendrite cell membrane time constant (ms) 17.1 ± 2.1 (21) 17.1 (ms) Data Table
Other Perirhinal cortex fast-spiking aspiny, varicose dendrite cell spike amplitude (mV) 81.3 ± 4.6 (21) 81.3 (mV) Data Table
Other Perirhinal cortex fast-spiking aspiny, varicose dendrite cell spike half-width (ms) 0.47 ± 0.05 (21) 0.47 (ms) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus regular-spiking spiny, multi-polar pyramidal cell input resistance (MΩ) 198.5 ± 18.5 (21) 198.5 (MΩ) Data Table
Other Parietal lobe fast-spiking aspiny, varicose dendrite cell resting membrane potential (mV) -69.2 ± 1.6 (7) -69.2 (mV) Data Table
Other Parietal lobe fast-spiking aspiny, varicose dendrite cell input resistance (MΩ) 395.1 ± 43.6 (7) 395.1 (MΩ) Data Table
Other Parietal lobe fast-spiking aspiny, varicose dendrite cell membrane time constant (ms) 19.2 ± 3.5 (7) 19.2 (ms) Data Table
Other Parietal lobe fast-spiking aspiny, varicose dendrite cell spike amplitude (mV) 87.4 ± 1.8 (7) 87.4 (mV) Data Table
Other Parietal lobe fast-spiking aspiny, varicose dendrite cell spike half-width (ms) 0.49 ± 0.04 (7) 0.49 (ms) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus regular-spiking spiny, multi-polar pyramidal cell membrane time constant (ms) 32.6 ± 3.2 (21) 32.6 (ms) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus regular-spiking spiny, multi-polar pyramidal cell spike amplitude (mV) 80.7 ± 1.7 (21) 80.7 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus regular-spiking spiny, multi-polar pyramidal cell spike half-width (ms) 1.24 ± 0.08 (21) 1.24 (ms) Data Table
Other Perirhinal cortex regular-spiking spiny, multi-polar pyramidal cell resting membrane potential (mV) -81.0 ± 1.4 (21) -81.0 (mV) Data Table
Other Perirhinal cortex regular-spiking spiny, multi-polar pyramidal cell input resistance (MΩ) 183.0 ± 12.3 (21) 183.0 (MΩ) Data Table
Other Perirhinal cortex regular-spiking spiny, multi-polar pyramidal cell membrane time constant (ms) 32.1 ± 2.4 (21) 32.1 (ms) Data Table
Other Perirhinal cortex regular-spiking spiny, multi-polar pyramidal cell spike amplitude (mV) 85.3 ± 2.1 (21) 85.3 (mV) Data Table
Other Perirhinal cortex regular-spiking spiny, multi-polar pyramidal cell spike half-width (ms) 1.15 ± 0.04 (21) 1.15 (ms) Data Table
Other Parietal lobe regular-spiking spiny, multi-polar pyramidal cell resting membrane potential (mV) -80.6 ± 1.0 (23) -80.6 (mV) Data Table
Other Parietal lobe regular-spiking spiny, multi-polar pyramidal cell input resistance (MΩ) 235.2 ± 19.5 (23) 235.2 (MΩ) Data Table
Other Parietal lobe regular-spiking spiny, multi-polar pyramidal cell membrane time constant (ms) 29.9 ± 1.2 (23) 29.9 (ms) Data Table
Other Parietal lobe regular-spiking spiny, multi-polar pyramidal cell spike amplitude (mV) 82.4 ± 1.3 (23) 82.4 (mV) Data Table
Other Parietal lobe regular-spiking spiny, multi-polar pyramidal cell spike half-width (ms) 1.1 ± 0.04 (23) 1.1 (ms) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus fast-spiking aspiny, varicose dendrite cell resting membrane potential (mV) -66.4 ± 1.6 (13) -66.4 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus fast-spiking aspiny, varicose dendrite cell input resistance (MΩ) 427.1 ± 45.7 (13) 427.1 (MΩ) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus fast-spiking aspiny, varicose dendrite cell membrane time constant (ms) 21.4 ± 2.6 (13) 21.4 (ms) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus fast-spiking aspiny, varicose dendrite cell spike amplitude (mV) 86.2 ± 3.1 (13) 86.2 (mV) Data Table
Amygdala basolateral nucleus pyramidal neuron Lateral Amygdaloid nucleus fast-spiking aspiny, varicose dendrite cell spike half-width (ms) 0.56 ± 0.04 (13) 0.56 (ms) Data Table
Other Perirhinal cortex fast-spiking aspiny, varicose dendrite cell resting membrane potential (mV) -68.0 ± 1.2 (21) -68.0 (mV) Data Table
Other Perirhinal cortex fast-spiking aspiny, varicose dendrite cell input resistance (MΩ) 352.8 ± 43.7 (21) 352.8 (MΩ) Data Table