mSOD1WT | hSOD1G93A | |
---|---|---|
Cell properties | ||
Resting membrane potential (mV) | −61 ± 3 | −63 ± 2 |
Input resistance (MΩ ) | 1061 ± 171 | 863 ± 145 |
Action potential properties | ||
Threshold (mV above resting MP) | 26 ± 3 | 25 ± 3 |
Amplitude (mV above threshold MP) | 61 ± 8 | 84 ± 6* |
Maximum rate of AP rise (mV/ms) | 109 ± 24 | 171 ± 26 |
Duration (ms) | 4.2 ± 0.5 | 3.1 ± 0.2 |
Half-width duration (ms) | 1.8 ± 0.2 | 1.5 ± 0.1 |
Afterhyperpolarization amplitude (mV below threshold MP) | −21 ± 2 | −21 ± 2 |
Number of cells | 8 | 7 |
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Averaged cell properties and AP properties (analyzed from single AP) are shown for mSOD1WT and hSOD1G93A SCs (P10–P12). AP threshold is relative to resting membrane for each SC recorded; AP and afterhyperpolarization amplitude are relative to AP threshold potential for each SC recorded. Note that only the AP amplitude is significantly increased in hSOD1G93A SCs. Statistical significance (Student's unpaired t test) is indicated. Data are mean ± SEM.