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Neostriatum medium spiny neuron (Definition)

Electrophysiological properties of Neostriatum medium spiny neurons from literature:

  • Reports: Blue dots indicate human-curated values; Orange dots indicate non-human curated values
  • Mean+SD: mean and standard deviation of human-curated neuron measurements
  • All neurons: mean and standard deviation computed over all neurons in database
  • Interactivity:
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  • Legend: Blue dots = text-mined values human curated; Orange dots = text-mined values not human curated

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Articles with extracted electrophysiology properties:

Article Title Authors Journal Year Electrophys values Neuron types
Dichotomous anatomical properties of adult striatal medium spiny neurons. (NeuroElectro data) (PubMed) Gertler TS; Chan CS; Surmeier DJ J. Neurosci. 2008 10 1
Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway. (NeuroElectro data) (PubMed) Wu N; Joshi PR; Cepeda C; Masliah E; Levine MS J. Neurosci. Res. 2010 9 1
A telencephalic nucleus essential for song learning contains neurons with physiological characteristics of both striatum and globus pallidus. (NeuroElectro data) (PubMed) Farries MA; Perkel DJ J. Neurosci. 2002 39 2
NMDA receptor function in mouse models of Huntington disease. (NeuroElectro data) (PubMed) Cepeda C; Ariano MA; Calvert CR; Flores-Hernández J; Chandler SH; Leavitt BR; Hayden MR; Levine MS J. Neurosci. Res. 2001 6 1
Differential electrophysiological properties of dopamine D1 and D2 receptor-containing striatal medium-sized spiny neurons. (NeuroElectro data) (PubMed) Cepeda C; André VM; Yamazaki I; Wu N; Kleiman-Weiner M; Levine MS Eur. J. Neurosci. 2008 16 1
A comparative voltage and current-clamp analysis of feedback and feedforward synaptic transmission in the striatal microcircuit in vitro. (NeuroElectro data) (PubMed) Gustafson N; Gireesh-Dharmaraj E; Czubayko U; Blackwell KT; Plenz D J. Neurophysiol. 2006 16 2
Inhibitory interactions between spiny projection neurons in the rat striatum. (NeuroElectro data) (PubMed) Tunstall MJ; Oorschot DE; Kean A; Wickens JR J. Neurophysiol. 2002 4 1
Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice. (NeuroElectro data) (PubMed) Klapstein GJ; Fisher RS; Zanjani H; Cepeda C; Jokel ES; Chesselet MF; Levine MS J. Neurophysiol. 2001 20 1
Dopamine D-1/D-5 receptor activation is required for long-term potentiation in the rat neostriatum in vitro. (NeuroElectro data) (PubMed) Kerr JN; Wickens JR J. Neurophysiol. 2001 6 1
Distinct roles of GABAergic interneurons in the regulation of striatal output pathways. (NeuroElectro data) (PubMed) Gittis AH; Nelson AB; Thwin MT; Palop JJ; Kreitzer AC J. Neurosci. 2010 20 3
Dopamine receptor activation is required for corticostriatal spike-timing-dependent plasticity. (NeuroElectro data) (PubMed) Pawlak V; Kerr JN J. Neurosci. 2008 9 1
The nitric oxide-guanylyl cyclase signaling pathway modulates membrane activity States and electrophysiological properties of striatal medium spiny neurons recorded in vivo. (NeuroElectro data) (PubMed) West AR; Grace AA J. Neurosci. 2004 16 1
Quantitative estimate of synaptic inputs to striatal neurons during up and down states in vitro. (NeuroElectro data) (PubMed) Blackwell KT; Czubayko U; Plenz D J. Neurosci. 2003 14 2
Dopamine modulates excitability of spiny neurons in the avian basal ganglia. (NeuroElectro data) (PubMed) Ding L; Perkel DJ J. Neurosci. 2002 21 1
Up and down states in striatal medium spiny neurons simultaneously recorded with spontaneous activity in fast-spiking interneurons studied in cortex-striatum-substantia nigra organotypic cultures. (NeuroElectro data) (PubMed) Plenz D; Kitai ST J. Neurosci. 1998 24 2
Cell-specific spike-timing-dependent plasticity in GABAergic and cholinergic interneurons in corticostriatal rat brain slices. (NeuroElectro data) (PubMed) Fino E; Deniau JM; Venance L J. Physiol. (Lond.) 2008 36 3
P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices. (NeuroElectro data) (PubMed) Coppi E; Pedata F; Gibb AJ J. Neurophysiol. 2012 9 1
Regulation of action-potential firing in spiny neurons of the rat neostriatum in vivo. (NeuroElectro data) (PubMed) Wickens JR; Wilson CJ J. Neurophysiol. 1998 5 1
NMDA receptor gating of information flow through the striatum in vivo. (NeuroElectro data) (PubMed) Pomata PE; Belluscio MA; Riquelme LA; Murer MG J. Neurosci. 2008 4 1
Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice. (NeuroElectro data) (PubMed) Levine MS; Altemus KL; Cepeda C; Cromwell HC; Crawford C; Ariano MA; Drago J; Sibley DR; Westphal H J. Neurosci. 1996 6 1
Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids. (NeuroElectro data) (PubMed) André VM; Cepeda C; Cummings DM; Jocoy EL; Fisher YE; William Yang X; Levine MS Eur. J. Neurosci. 2010 6 1
Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin. (NeuroElectro data) (PubMed) Dvorzhak A; Semtner M; Faber DS; Grantyn R J. Physiol. (Lond.) 2013 4 1
Epilepsy-induced abnormal striatal plasticity in Bassoon mutant mice. (NeuroElectro data) (PubMed) Ghiglieri V; Picconi B; Sgobio C; Bagetta V; Barone I; Paillè V; Di Filippo M; Polli F; Gardoni F; Altrock W; Gundelfinger ED; De Sarro G; Bernardi G; Ammassari-Teule M; Di Luca M; Calabresi P Eur. J. Neurosci. 2009 8 2
Enhanced high-frequency membrane potential fluctuations control spike output in striatal fast-spiking interneurones in vivo. (NeuroElectro data) (PubMed) Schulz JM; Pitcher TL; Savanthrapadian S; Wickens JR; Oswald MJ; Reynolds JN J. Physiol. (Lond.) 2011 29 3
Functional and molecular development of striatal fast-spiking GABAergic interneurons and their cortical inputs. (NeuroElectro data) (PubMed) Plotkin JL; Wu N; Chesselet MF; Levine MS Eur. J. Neurosci. 2005 28 2
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. (NeuroElectro data) (PubMed) Pisani A; Gubellini P; Bonsi P; Conquet F; Picconi B; Centonze D; Bernardi G; Calabresi P Neuroscience 2001 4 1
Substantia nigra dopamine regulates synaptic plasticity and membrane potential fluctuations in the rat neostriatum, in vivo. (NeuroElectro data) (PubMed) Reynolds JN; Wickens JR Neuroscience 2000 11 1
Receptor subtype-specific modulation by dopamine of glutamatergic responses in striatal medium spiny neurons. (NeuroElectro data) (PubMed) Lin JY; Dubey R; Funk GD; Lipski J Brain Res. 2003 18 3
The corticostriatal input to giant aspiny interneurons in the rat: a candidate pathway for synchronising the response to reward-related cues. (NeuroElectro data) (PubMed) Reynolds JN; Wickens JR Brain Res. 2004 14 2
Differences in striatal spiny neuron action potentials between the spontaneously hypertensive and Wistar-Kyoto rat strains. (NeuroElectro data) (PubMed) Pitcher TL; Wickens JR; Reynolds JN Neuroscience 2007 9 1
Heterogeneity of spike frequency adaptation among medium spiny neurones from the rat striatum. (NeuroElectro data) (PubMed) Venance L; Glowinski J Neuroscience 2003 43 3
Dopamine D2 receptors regulate collateral inhibition between striatal medium spiny neurons. (NeuroElectro data) (PubMed) Lalchandani RR; van der Goes MS; Partridge JG; Vicini S J. Neurosci. 2013 6 1
Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine. (NeuroElectro data) (PubMed) Planert H; Berger TK; Silberberg G PLoS ONE 2013 36 1
Inositol 1,4,5-triphosphate drives glutamatergic and cholinergic inhibition selectively in spiny projection neurons in the striatum. (NeuroElectro data) (PubMed) Clements MA; Swapna I; Morikawa H J. Neurosci. 2013 24 1
Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure. (NeuroElectro data) (PubMed) Wang W; Darvas M; Storey GP; Bamford IJ; Gibbs JT; Palmiter RD; Bamford NS J. Neurosci. 2013 27 2
Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons. (NeuroElectro data) (PubMed) Dorris DM; Cao J; Willett JA; Hauser CA; Meitzen J J. Neurophysiol. 2015 26 1

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